THE EFFECT OF AVOCADO (PERSEA AMERICANA MILL.) LEAVES EXTRACT TOWARDS THE MOUSE’S BLOOD GLUCOSE DECREASE WITH THE GLUCOSE TOLERANCE METHODAbstract
Decrease in blood glucose level test with the use of oral glucose tolerance method from Avocado leaves was carried out. Swiss Webster male mice were divided randomly into five groups. They were negative control, positive control (Glipizide 0.013 mg/20 g BW) and three test groups treated with dosage of avocado leaves ethanol extract 0.490 g/kg, 0.980 g/kg and 1.960 g /BW respectively. Experiment was begun with feeding the mice with the test solution followed by feeding glucose solution (1.5 g/kg BW) 30 minutes later. Blood glucose levels were assessed using glucometer kit, from zero to 3 hours, at ½ hourly interval. These results analysed by one way ANOVA showed there were significant difference (p<0.05) between Ethanol extract of avocado leaves treated with mice (0.490, 0.980 g/kg BW) and control groups.Furthermore, when Tukey’s test was performed, avocado treated mice (1.960g/kg BW) reduce glucose level to 64.27%. The effectiveness of this treatment was not significantly different to those treated with glipizide (68.50%).
Shirly Kumala*, Hesty Utami* and Wahyu Kartika Sari
Pharmacy Faculty, Pancasila University, Srengseng Sawah, Jagakarsa, Jakarta, Indonesia
18 September, 2012
29 November, 2012
26 January, 2013
01 February, 2013