THE EFFECT OF FORMULA TO PHYSICAL PROPERTIES OF WOUND HEALING GEL OF ETHANOLIC EXTRACT OF BINAHONG (ANREDERA CORDIFOLIA (TEN) STEENIS)Abstract
Binahong (Anredera cordifolia (Ten) Steenis) has been used as wound healing in traditional Indonesian medicine and it is relevant to develop dosage forms of binahong using formulation technology approach. The aim of this research was to find out wound healing gel formula of ethanolic extract of binahong. The factorial design method 3 factors and 2 levels were employed to achieve this study. Three factors used in this study were Carbopol, Na-CMC and Ca-alginate with low and high level for each factor. The wound healing gel of ethanolic extract of binahong was evaluated for their physical properties i.e viscosity, spreadability, extrudability and bioadhesive properties. The results of this research were carbopol and Ca-alginate affecting physical properties of wound healing gel of ethanolic extract of binahong. Na-CMC affected physical properties of the gel except bioadhesive properties. Carbopol provided the greatest contribution to viscosity, spreadability, extrudability and bioadhesive properties of the gel.
S.H. Yuliani*, A. Fudholi , S. Pramono and Marchaban
Jl. Gatotkaca 16A Wirobrajan, Yogyakarta 55252, Indonesia
06 July, 2012
19 August, 2012
20 October, 2012