THE EFFECT OF GINGER-JUICE (ZINGIBER OFFICINALE ROSCOE) ON LITHIUM-INDUCED LOCOMOTOR ACTIVITY IN RATAbstract
Ginger has shown to benefit in muscular pain due to eccentric exercise and in osteoarthritis but a later review denied these properties due to uncertainties. To ascertain the reality, this study was proposed. Methods: (A) Albino rats (n=6-12) were administered G.J at single dose (4 ml/rat, p.o) as single administration (acute) and chronic treatment 4ml/rat p.o over period of 7 days. Following this assessment was done. Effect of treatment with G.J acutely and chronically (7 days) administered, was assessed. Parameter used during assessment was head twitches. Results: Chronic treatment of ginger-juice induced the head twitches significantly. Acute treatment with ginger-juice did not affect this activity. Chronic treatment increased the number of head twitches induced by lithium. Conclusion: Lithium induced head twitches were enhanced after chronic administration of ginger-juice.
S. S. Prasad *, R. R. Pathak, S. K. Vajpeyee and V. H. Bhavsar
Department of Pharmacology, GMERS Medical College, Himmatnagar, Gujarat, India.
15 September, 2015
20 February, 2017
24 February, 2017
01 April, 2017