THE EVALUATION OF THE PRIMARY BONE TUMORS BY BONE MARKERSAbstract
Serum markers reflect a bone cell activity that regulate bone remodeling, bone alkaline phosphatase (PAO), Total Intact Procollagen Type I N-terminal propeptide (TP1NP) for training and tartrate-resistant acid phosphatase (TRAPB5), carboxy-terminal collagen crosslinks (Cross Laps) for bone resorption. These markers are sensitive and early tools, Elevated serum levels of these markers is a very good prognostic factor of primary bone tumors as well as monitoring and evaluation tools. We investigated whether biomarkers of bone formation (PAO, P1NP) and bone resorption (CTX and TRAPb5) were modified by chemotherapy. The aim of this study was to evaluate the impact of treatment on serum PAO and TP1NP and TP1NP and TRAPB5. Result: We found a significant correlation between serum levels of training biomarkers (PAO and TP1NP in the group of patients (p = 0.0042) and a strong correlation between PAO and TP1NP In the sick and control groups (p = 0.00027) and a strong correlation between TP1NP and TRAP5b in the groups of patients and controls (p = 0.033). Bone markers can be used in therapeutic monitoring of experimental bone disorders and to assess remodeling during chemotherapy for primary tumors.
K. Samy, M. Cohen Solal, C. Collet, A. Ostertag, M. Rabeh, L. Rouabah and A. Rouabah
Department of Biochemistry and Cellular and Molecular Biology, Faculty of Sscience, University of Constantine, Algeria
04 July, 2016
16 August, 2016
02 September, 2016
01 January, 2017