THE PHARMACOLOGICAL ACTIONS OF IRIFLOPHENONE-3-C-β-D GLUCOSIDE: AN OVER VIEWAbstract
Iriflophenone 3-C-β-D glucoside is a Benzophenone derivative which can be obtained from various plant sources like Aquilaria crassna, A. sinensis, A. malaccensis, Cyclopia genistoides, Mangifera indica, Dryopteris ramosa etc. It can act as an important herbal active constituent as it has various pharmacological actions, such as Antidiabetic, anti-inflammatory, antioxidant, and antimicrobial agent. Some scientists demonstrated the antioxidant activity of Iriflophenone 3-C-β-D glucoside and have seen that this compound has no radical scavenging ability against DPPH [2,2-diphenylpicrylhydrazyl] but scavenged ABTS [2,2’-azino-bis(3- ethylbenzothiazoline-6-sulphonic acid)] and peroxyl radicals. So, it can be used as an anti- oxidant agent. From A. sinensis 8 compounds were isolated among which Iriflophenone 3-C- β-D glucoside was present. It is proved that all the isolated compounds have α-glucosidase inhibition activity stronger than acarbose, that is taken as positive drug control. Aqueous fraction of D. ramosa is used for so long by the inhabitants of the Galliyat region of Pakistan to treat their GIT ailments caused by bacteria. Scientists showed that Iriflophenone 3-C-β-D glucoside that is obtained from Dryopteris ramosa has stronger antibacterial potential against Klebsiella pneumoniae, Staphylococcus aureus, and Escherichia coli. The anti-inflammatory activities of this compound are revealed as the aqueous extract of A. crassna expressed strong IL-1α and IL-8 inhibitions and the 70% Ethanolic extract showed IL-1α and NO inhibitions. Apart from this there are many other effects of that compound which are still under research. Such versatile uses make this compound a highly valuable herbal constituent.
Debtanu Bhattacharyya, Satadru Nag and Anuranjita Kundu *
Department of Pharmaceutical Science, Guru Nanak Institute of Pharmaceutical Science and Technology Kolkata, West Bengal, India.
02 January 2023
21 March 2023
30 May 2023
01 September 2023