THE PROTECTIVE EFFECTS ABELMOSCHUS ESCULENTUS PODS SKIN AND SEEDS AGAINST NICOTINE INDUCED LIVER, KIDNEY DAMAGE IN MICE’

Abelmoschus esculentus is one of the oldest urbane crops grown in many countries and widely distributed. Parts used of okra are fruit, leave seed, root wish showed to have numerous Medicinal significant uses. On the other hand, cigarette, smokers found to have a high a significant effect on liver kidney and other numerous organs in the body. Aim: The study aims to explore the possible protective effects of three parts of okra against nicotine-induced damage in many parts of the mice body. Methods: Fifty male Swiss albino mice were used throughout the study. After tow-weeks acclimatization period, the mice divided into 5 groups from the control group, nicotine-treated group, nicotine-okra pods extract -treated group, nicotine-okra skin extract treated group, and nicotine-okra seeds extract -treated group. Result: shown significant protective effects against nicotine damage effects as cholesterol level decrease in okra skin treatment with a significant difference in comparison with the positive group also okra protective effects on renal function have found that urea and creatinine levels decrease significantly in okra feeding mice. Liver function tests have also been evaluated, and SGPT levels of all okra parts extract have shown significant differences decrease compared to the positive control group. Conclusion: Abelmoschus esculentus possess effects like normalizing cholesterol levels, (antihyperlipidemic roles), suggesting that the consumption of okra may be of benefit in metabolic diseases.