THE PROTECTIVE ROLE OF COLCHICINE ON DICLOFENAC SODIUM INDUCED HEPATORENAL TOXICITY IN ALBINO RATS MODELAbstract
Diclofenac (DIC) is a widely used as an anti-inflammatory drug and it is used as the toxicant in hepatoprotective studies. In the present study, hepato-renal protective activity of Colchicine against DIC induced liver and kidney injury in albino rats was assessed. Animals were injected with Diclofenac sodium at the single dose of 150 mg/ kg body weight daily for 28 days. Oral administration of colchicine at a concentration of 10µg/kg b.w daily for 28 days showed a significant decrease in plasma AST, ALT and creatinine as well as hepatic and renal thiobarbituric acid reactive substances and hydroperoxides. The treatment also resulted in a significant increase in GSH, SOD, CAT and GPx in the liver and kidney of DIC treated rats. The results clearly suggest that the colchicine treated group may effectively normalize the impaired antioxidant status in DIC- induced liver and kidney injury than the vitamin C-treated groups. However, Colchicine rapid protective effects against lipid peroxidation by scavenging of free radicals reduce the risk of oxidative complications.
Sylvia A. Boshra and Mohammed A. Hussein*
Biochemistry Department, Faculty of Pharmacy, October 6th University, 6th October city, Egypt.
13 May, 2014
13 July, 2014
15 August, 2014
01 December 2014