THE STUDY OF SERUM VITAMIN D STATUS WITH INSULIN RESISTANCE IN OBESE ADOLESCENTSAbstract
Aim: To study the relationship between serum Vitamin D levels and insulin resistance in obese and non obese adolescents. Introduction: Vitamin D deficiency in obese adolescent is strongly associated with increased risk for diabetes, hyper tension and metabolic syndrome. Vitamin D insufficiency is a risk factor for developing impaired glucose in childhood obesity and is associated with insulin resistance in obese adolescents. In our study, we examined the relationship between Vitamin D and insulin resistance in obese adolescents. Materials and Methods: The study group included 50 obese adolescent aged (17-19 years) and compared with 50 age and gender matched healthy controls. Anthropometric data were collected and fasting plasma glucose was estimated by (GOD-POD) method, serum Insulin was estimated by (FEIA) method and insulin resistance was calculated by using (HOMA-IR) and serum Vitamin D was measured by using ELISA method. Results: The Vitamin D levels in obese adolescents is slightly lower than the controls. The insulin levels in obese adolescents is slightly higher than controls. Insulin resistance was significantly higher in subjects with higher BMI. We found by correlation analysis that HOMA-IR was dependent on degree of obesity and independent of Vitamin D level. Conclusion: The study concludes that in obese adolescents insulin resistance was affected more from BMI than Vitamin D levels. Lower concentration of Vitamin D is also a risk factor for developing insulin resistance independent of adiposity.
Sarguru Datchinamoorthi *, Vanaja R and Balaji Rajagopalan
Department of Biochemistry, Shri Sathya Sai Medical College and Research Institute, Chennai, Tamilnadu, India
24 June, 2016
02 September, 2016
08 November, 2016
01 December, 2016