THE STUDY ON OPTIMIZATION OF SOLID ORAL FLOATING TABLETS-A REVIEWAbstract
The motivation behind composing this review on floating drug delivery systems (FDDS) was to incorporate the ongoing research article with a unique spotlight on the key system of floatation to accomplish gastric maintenance. The ongoing advancements of FDDS, including the physiological and formulation factors influencing gastric maintenance, ways to deal with configuration single-unit, and numerous unit of floating drug delivery systems, and their grouping and formulations perspectives are canvassed in detail. This review has a special focus on the principal mechanism of floatation to achieve gastric retention. Conventional oral dosage forms have short residence times & unpredictable gastric emptying time. The idea of gastric retention comes from the need to localize drugs at a specific region of the gastrointestinal tract (GIT), such as the stomach in the body. Many drugs get absorbed only in the upper intestinal tract, designing such molecules as once-daily formulations are exclusive for these molecules. Thus, gastro retention could help to provide greater availability of new products and consequently improved therapeutic activity and substantial benefits to patients. This article aims at reviewing the floating drug delivery system, including types, approaches for designing the floating dosage form, advantages & disadvantages of FDDS. This drug delivery system is valuable to a few issues experienced during the advancement of a pharmaceutical dosage form.
R. Pawar * and S. Jagdale
Department of Pharmaceutics, MAEER’s MIT College of Pharmacy, MIT Campus, Pune, Maharashtra, India.
23 March 2020
30 April 2020
15 May 2020
01 March 2021