TO ESTABLISH THE ULCEROGENIC POTENTIAL IF ANY, OF GINGER-JUICE ZINGIBER OFFICINALE ROSCOE (ZINGIBERACEAE) ON IMPORTANT PARAMETERS OF GASTRIC ULCERATIONAbstract
The aim of this study was to investigate the possibility of gastric-ulceration by ginger-juice (Zingiber officinale Roscoe) in rat. (A) Albino rats (n=6-12) were administered G.J at two doses (2ml & 4 ml/rat, p.o) as single administration and chronic treatment over period of 30 days. Following this assessment was done for possible gastric lesion. Effect of treatment with G.J acutely and chronically (30 days) administered, was assessed. Parameters used during assessment were total acidity, gastric volume & pH and ulcer index ‘UI’ (acute and chronic). Acute & chronic administration of G.J (2ml & 4ml/rat, p.o) caused an increase in pH and vol. of gastric content, a decrease in total acidity and no significant change in ulcer index.
S.S. Prasad*, Anita Sinha, Kamlesh Patel, Chandresh Dumatar, S.K. Vajpeyee and V.H. Bhavsar
Department of Pharmacology, C.U. Shah Medical College, Surendranagar -363001, Gujarat, India
27 July, 2012
17 September, 2012
21 October, 2012