TO EVALUATE RHEOLOGICAL SYNERGISM BY COMBINING HYDROPHILIC POLYMERS AND OPTIMIZATION BY SIMPLEX MIXTURE DESIGNAbstract
It appears that you have conducted a study on the preparation of Glipizide sustained-release tablets using different HPMC (hydroxypropyl methylcellulose) polymers of varying viscosity grades, specifically HPMCK 4M and HPMC K 15M, in different proportions. The concentration of the polymers was optimized using a simplex mixture design, with HPMC K4M, HPMC K15M and lactose as the components of the mixture. The tablets were prepared using the wet granulation method. According to your study, the prepared tablets exhibited polymeric synergism, which was confirmed through in-vitro dissolution testing. Both HPMC K4M and HPMC K15M showed a synergistic effect on the T50% drug release. However, HPMC K15M demonstrated a dominant effect compared to HPMC K4M due to its higher viscosity. It seems that the higher viscosity of HPMC K15M contributed to a more sustained drug release profile in the tablets. This finding suggests that HPMC K15M played a more significant role in controlling the release rate of Glipizide from the tablets, as compared to HPMC K4M.
Ashwini R. Madgulkar, Mangesh R. Bhalekar and Yash Abhay Saoji *
Department of Pharmaceutics, AISSMS College of Pharmacy, Savitribai Phule Pune University, Pune, Maharashtra, India.
10 March 2023
16 August 2023
25 August 2023
01 November 2023