TO EVALUATE THE EFFECTIVENESS OF SOLID DISPERSION IN FORMULATION OF FAST DISINTEGRATING TABLETSAbstract
Flurbiprofen is a water insoluble non-steroidal anti inflammatory drug and belongs to BCS Class II categories. Solid dispersion is a technique by which we can improve it water solubility. By the help of fast dissolving formulation we can evaluate the effectiveness of solid dispersion. In this research work the solid dispersion of flurbiprofen with polymer like PVP K25, PVP K30, PVP K29-32, and PEG 6000 in different ratio (1:1 -1:5) were formulated the optimized batch was selected on the basis of dissolution test and other evaluation parameter like IR, DSC, TLC, etc. Fast dissolving tablets were formulated of optimized solid dispersion batch by direct compression method using superdisintegrants like crosspovidone, crosscarmellose sodium (2.5% to 77%). The prepared tablets were found to comply with various official specifications. The dissolution release rate from all optimized batches were studied and found to be 99.9% in 4 minutes in case of formulation containing 60% of crosspovidone.
Avnish Kumar Prajapati*, Arun Kumar Singh, Meenakshi Bajpai, Ashwani Chaturvedi and Ammeduzaffer
Raj Kumar Goel Institute of Technology, Department of Pharmacy, Ghaziabad (UP), India
15 May, 2010
17 July, 2010
25 August, 2010
15 September, 2010