TOPICAL DRUG DELIVERY OF KETOCONAZOLE ENTRAPPED TRANSFEROSOMAL GEL WITH DESIGN AND ENACTMENTAbstract
In pharmaceutical research, the transdermal route of drug delivery has gained great interest, Trasferosomes is a novel vesicular drug carrier system that is composed of water, surfactant, and phospholipids; these were introduced in the early 1990s. The mechanism on which drugs absorb through skin is “osmotic gradient”. Transferosomes, when applied on the skin surface it diffuses into skin layers and provides smoothness and hydration to the skin, which facilitates drug absorption. The transferosomal gel of ketoconazole was prepared with the aim to achieve higher diffusion through the skin for the treatment of acne with minimum or no side effects. The formulations were prepared by the reverse-phase evaporation method. Formulations were prepared by varying the ratio of soya lecithin and cholesterol by maintaining room temperature.
Lovely Chaurasia *, Anuj Pradhania, Sakshi Garg and Gargi Gupta
IIMT College of Medical Sciences, Meerut, Uttar Pradesh, India.
27 January 2021
20 May 2021
29 May 2021
01 December 2021