TOXICITY STUDIES OF BOUGAINVILLEA GLABRA AND MUCUNA PRURIENSAbstract
The present study was aimed to evaluate the acute toxicity study and subchronic toxicity study with methanol extracts of Bougainvillea glabra and Mucuna pruriens on Wistar albino rats. The acute dose was administered at 2000 mg/kg body weight on 1st day and observed for 14 days, while chronic dose was given at 250, 500, and 1000 mg/kg b.w. for 90 days. In subchronic toxicity study, hematological (Platelet count, RBC, WBC, hemoglobin, MCV & MCH) and biochemical studies (SGOT, SGPT, ALP, creatinine, urea & bilirubin) were carried out from plasma and serum after completion of 90 days treatment period. During the treatment period, the rats were observed for toxicity symptoms and, in addition to mortality & bodyweight alterations, were documented. In the result of acute toxicity study, methanol extracts of Bougainvillea glabra and Mucuna pruriens were found to be non-toxic at a dose of 2000 mg/kg b.w. Similarly, no significant difference was observed in hematological analysis and biochemical parameters from control groups and test animals in the subchronic toxicity study. The findings suggested that methanol extracts of Bougainvillea glabra and Mucuna pruriens were well tolerated both in acute and subchronic toxicity studies.
R. G. Krishna and R. Sundararajan *
GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, India.
13 October 2019
09 March 2020
13 March 2020
01 October 2020