TOXICOLOGICAL EVALUATION OF TRIVANGA BHASMA (TRIMETALLIC AYURVEDIC FORMULATION) IN ANIMAL MODEL VIA 28-DAY REPEATED ORAL DOSEAbstract
Context: Ayurveda emphasizes applying herbal, metallic, mineral, and herbo-mineral preparations in therapeutics. Trivanga Bhasma (TB) is a potential trimetallic (Tin, Lead & Zinc) compound formulation widely used in routine Ayurvedic practice to treat several chronic ailments. Objective: To elucidate the toxicity profile of TB by oral administration in wistar albino rats to ascertain the safety aspects. Method: TB was administered in possible higher doses such as TED (Therapeutic Equivalent Dose), TED × 2 (2 times the Therapeutic Equivalent Dose), TED × 5 (5 times the Therapeutic Equivalent Dose) and TED × 10 (10 times the Therapeutic Equivalent Dose) for 28 days. The effect was assessed on ponderal changes, biochemical parameters, histopathology, and tissue analysis. Results: Results showed that TB did not induce any toxicity at TED, TED × 2, TED × 5; whereas histopathology and tissue analysis of very higher dose TED × 10 exhibited toxicity in the liver & kidney. Conclusion: The drug, however, at a dose of TEDx10 showed mild undesirable changes in the liver & kidney; the experiential variations were not observed at TED (Therapeutic Equivalent Dose) and TED × 2 (2 times the Therapeutic Equivalent Dose). Hence, it is concluded that the Trivanga Bhasma prepared as per the classical method is safe for consumption at the recommended therapeutic dose level.
Smitha Jain *, Tamatum Anand, Farhath Khanum and Ashok D. Satpute
Department of Rasashastra & Bhaishajya Kalpana, JSS Ayurveda Medical College, Mysuru, Karnataka, India.
15 October 2020
05 March 2021
29 November 2021
01 May 2022