TRANSDERMAL PENETRATION EFFICACY OF ETHOSOMAL SYSTEMS WITH AND WITHOUT PENETRATION ENHANCER: A COMPARATIVE STUDYAbstract
Ethosomal systems are now a days attracting attention of many researchers. This study is designed to observe the effect of penetration enhancers in ethosomal formulations. Ascorbic acid is taken as a model drug; phosphatidylcholine and ethanol are taken for ethosome preparation. Propylene glycol is taken as a penetration enhancer. Ethosomes are prepared by solvent dispersion method with and without penetration enhancer. The drug release profile is compared. Dialysis membrane and human cadaver skin are taken for penetration study. In this study the ethosomes which were prepared by adding penetration enhancers showed better penetration efficiency.