TWO LAYER MODEL TO SIMULATE TRANSDERMAL DRUG DELIVERY FOR SKIN PSORIASISAbstract
Psoriasis is a non-infectious, dry, inflammatory skin disorder. It results in patches of thick, red skin covered with silvery scales. Transdermal drug delivery is used to deliver drugs through the skin, but the skin is an effective barrier and provides resistance to drug delivery. To improve drug delivery through the skin, permeation enhancers are used. The simulation using the COMSOL software will help to treat the psoriasis skin in a non-invasive manner. The main objective is to create a psoriasis skin model that replicates skin psoriasis properties. Designing a psoriasis skin model using COMSOL Multi-physics software helps to understand the biomechanical properties of the skin when the transdermal drug and the permeation enhancer are delivered. Transepidermal water loss (TEWL or TWL) is one of the causes of psoriasis. It is the loss of water that passes from inside a body through the epidermis to the surrounding atmosphere through diffusion and evaporation processes. To reduce the Transepidermal water loss, the transdermal drug carriers like Liposomes, Niosomes, and Ethosomes are delivered inside the skin along with the drug Calcipotriol. Our results showed that the Niosomes has a better capacity to reduce the amount of water lost in the epidermis than the Ethosomes and conventional Liposomes. Accordingly, it can be put forth that the Niosomes show a lesser recovery period for the psoriasis disease. Thus, the noisome can be used as a future transdermal drug carrier for the treatment of psoriasis.
S. V. Preethi *, S. M. Cherian and T. Jayashree
Department of Biomedical Engineering, Vel Tech Rangarajan Dr. Sagunthala R & D Institute of Science and Technology, Avadi, Tamil Nadu, India.
31 December 2019
16 April 2020
20 April 2020
01 January 2021