UNDERSTANDING OF PHYTO-NANOMEDICINE FOR THE MANAGEMENT OF INFLAMMATION AND WOUND HEALING: AN OUTLOOKAbstract
Nanoparticles are the modern-day drug delivery system for biocompatible drugs. Numerous products have developed from nanotechnology to develop effective wound healing and inflammatory treatments. Plant extracts (phytoconstituents) have a lot of therapeutically potential because of their distinctive properties, including anti-inflammatory, antioxidant and insulin-sensitizing properties etc. Furthermore, the nanostructure of herbal extracts and phytoconstituents could enhance the bioavailability, influence relieves of the manner of drug carrier systems to the wounded area, and increase permeation ability to the underlying layers of the skin, all of which are essential for the recovery process and treating inflammation. This review emphasizes nano-formulations of plant extracts. Many approaches have already been published for the preparation of metal nanoparticles, including laser ablation, evaporation-condensation, thermal-decomposition, chemical reduction, photochemical processes, and biological methods (Green synthesis of metal nanoparticles utilizing diverse herbal extracts). Some herbal extracts and their phytochemicals are classified as a potential substitute for wound healing and treating inflammation intermediates due to the presence of various bioactive ingredients, the ease of access, and the reduction of adverse effects. Overall, when employed in nano-formulations, various herbal extracts and related phytoconstituents have shown excellent effectiveness in treating wounds and inflammation and could be considered as possible pharmaceutical medications in the future. This review provides a conceptual information of various herbal based nanoparticles for the management of inflammation and wound healing.
Deepika Aggarwal, Kamal *, Manjusha Choudhary, Gaurav Agarwal, Ashish Kumar and Diksha Sharma
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana, India.
22 January 2023
01 April 2023
31 May 2023
01 October 2023