USE OF LIPOSOMES IN CANCER THERAPY: A REVIEWAbstract
Cancer is uncontrolled growth of abnormal cells in the body. The cells causing cancer are called malignant cells. There are so many means by which one can treat the cancer such as chemotherapy, radiation treatment, surgery, etc. With all these treatments there are some side effects as loss of hairs, living cells may get killed, for surgery skilled persons are required and chances of reoccurrences are high. As per those side effects there is less popularity of such drugs. To overcome these problems and side effects liposomal treatment is useful. Liposomal drugs have high encapsulation capacity, hence shows a significant anticancer activity with decreased toxicity preferentially cadiotoxicity. These liposomal treatments have great prolonged circulation as in daunorubicin and pegylated liposomal doxorubicin. This liposomal drug delivery also developed for delivery of various drugs. Further generation of drug delivery systems will include true molecular targeting, immunoliposomes and other ligand directed constructs that represent emphasize on biological components capable of tumor recognition with delivery technologies.
Harshal R. Pawar, Sagar S. Bhosale, Nikita D. Derle*
Department of Pharmaceutics, M.V.P.s’ College of Pharmacy, Nashik-422002, Maharashtra, India
29 June, 2012
11 September, 2012
21 September, 2012