USING IMMUNOINFORMATIC APPROACH DESIGN EPITOPE-BASED VACCINE FOR CHIKUNGUNYA VIRUS
AbstractChikungunya is a mosquito-borne infection of the genus alphavirus. It is vaccines, medications, and other treatments difficult to produce. The CHIK-Virus is carried thru the mosquito, which functions as a vector for the disease. Vaccines, therefore, provide alternate preventative techniques for the spread of viral infection. Structural proteins of CHIK-Virus with T and B cells had been used for immuno-informatic approach. The identification of epitopes is a critical step in the development of vaccines against infectious illnesses. The author of this research work used scientific forte databases to choose the binding interactions of the epitopes PLVPRNAEL and RNEATDGTL have been created for a vaccine that contained non-toxic, non-allergenic, however tremendously antigenic determined in Asia, Africa, and Central South America. As a result of it’s far a high-quality feel polymer virus. The replication of CHIKV in the host results in genome mutation, making T-cells from CHIKV. Finally, epitopes acknowledged thru molecular docking research can be wont to supply huge spectrum vaccines, which might be powerful in opposition to numerous lines of Chikungunya.
Article Information
11
2662-2672
819 KB
424
English
IJPSR
Neeraj Kumar Dixit
Department of Biotechnology, Saroj Institute of Technology & Management, Lucknow, Utter Pradesh, India.
ndixitlip@gmail.com
07 October 2021
26 November 2021
22 December 2021
10.13040/IJPSR.0975-8232.13(7).2662-72
01 July 2022
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