USING OF INFORMATIONAL PARAMETERS AS A CRITERION FOR DETERMINING THE EFFECTIVENESS OF BIOSTIMULATION WITH USE OF TISSUE PREPARATIONSAbstract
Possibility of use of the informational parameters, which characterize adaptational and regenerative opportunities of organ, as potential criteria for the assessment of biological activity of tissue preparations, is investigated in this research. The influence of tissue preparation «STEMB» on the morphofunctional condition of a liver of rats at experimental toxic damage of organs was studied. The assessment of a morphofunctional condition of a liver under the influence of preparation was carried out as with use of traditional morphological, biochemical and histologic parameters, and also by means of informational parameters. A correlation analysis was conducted between the used biochemical, morphological and morphometric parameters and informational criteria. As a result of research it is established that hepatoprotective activity of preparation «STEMB» is confirmed both with results of traditional techniques of an assessment and with informational parameters, that allows drawing a conclusion on possibility of use of informational parameters as criterion of an estimation of biological activity of tissue preparations.
D. A. Areshidze *, M. A. Kozlova, L. A. Makartseva, A. A. Gritsyunayte, K. A. Sakhnova and E. A. Shmigelskiy
Researching Laboratory of Experimental Biology and Biotechnology, Moscow State Regional University, Moscow, Russian Federation.
04 June 2019
18 October 2019
30 November 2019
01 April 2020