UTILIZING MUCOADHESIVE POLYMERS FOR NASAL DRUG DELIVERY SYSTEMAbstract
Nasal drug delivery has been recognized as a promising route for delivery of therapeutic compounds including biopharmaceuticals. It has been demonstrated that absorption of drugs can enhanced by using absorption enhancers or increasing the drug residence time in the nasal cavity. Mucoadhesive polymers can serve both functions. The residence time in the nasal cavity is considerably increased for microspheres compared to solutions. However, this is not the only factor to increase the absorption of large hydrophilic drugs. Microspheres also exert a direct effect on the mucosa, resulting in the opening of tight junctions between the epithelial cells. This review focuses on the background of nasal mucoadhesive drug delivery with special references to the biological and pharmaceutical considerations for nasal mucoadhesive drug administration.
Rahul H. Kirange * and Ram B. Chaudhari
S. Zhaveri Pharmakem Pvt. Ltd., Kalyan - shilphata rd, Dombivli East, Maharashtra, India.
11 September, 2016
30 November, 2016
06 December, 2016
01 March, 2017