UV-SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF EFAVIRENZ IN BULK AND TABLET DOSAGE FORMAbstract
A simple, precise and accurate UV-Spectrophotometric method has been developed and validated for estimation of Efavirenz in bulk and tablet dosage form. It shows maximum absorbance at 320 nm with methanol and water (30:70). Estimation was carried out by A(1%1cm) and by comparison with standard. Calibration graph was found to be linear (r2 =0.09657) over concentration range of 1-4μg/ml. The proposed methods appear to be simple, sensitive, and reproducible when checked for parameters like accuracy, precision, limit of detection for routine determination of Efavirenz in bulk as well as in tablet. The methods can be adopted in its routine analysis.
Muni Bhaskar Reddy Chagam Reddy* and G. Venkata Subbareddy Gillella
Rayalaseema University, Kurnool- 518002, Andhra Pradesh, India
29 August, 2012
01 November, 2012
29 November, 2012
01 December, 2012