UV-SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF SECNIDAZOLE IN BULK AND TABLET DOSAGE FORMAbstract
A simple, precise and accurate UV-Spectrophotometric method has been developed and validated for estimation of secnidazole in bulk and tablet dosage form. It shows maximum absorbance at 313 nm with methanol and water (30:70). Estimation was carried out by A(1%1cm) and by comparison with standard. Calibration graph was found to be linear (r2 =0.09998) over concentration range of 1-4µg/ml. The proposed methods appear to be simple, sensitive, and reproducible when checked for parameters like accuracy, precision, limit of detection for routine determination of secnidazole in bulk as well as in tablet. The methods can be adopted in its routine analysis.
Jinendra M. Sonpetkar*, Deval V. Joshi, Nakul B. Patel and Mansi J. Wagdarikar
Indira College of Pharmacy, Tathwade, New Mumbai-Pune Highway, Pune- 411041, Maharashtra, India
06 October, 2011
18 November, 2011
28 January, 2012