VARIOUS ANIMAL MODELS FOR PRECLINICAL TESTING OF ANTI-INFLAMMATORY AGENTSAbstract
Inflammation is the local defensive response of living tissues to injury or due to any other chemical agents. Inflammation consists of two basic processes early inflammatory response later followed by healing. There are two types of inflammation, acute and chronic. The different animal models (i.e. vascular permeability, UV-erythema in guinea pigs, Croton-oil ear edema in rats and mice, Paw edema in rats, Collagen Induced Arthritis, Adjuvant Induced Arthritis, and Papaya Latex Induced Arthritis) are used for evaluation of anti-inflammatory activity for pre clinical study. Animal models of inflammation are used to study pathogenesis of ailments and to evaluate potential anti-inflammatory drugs for clinical use. This review article addresses the inflammatory characteristics and similarities between varieties of animal models of humans.
R. K. Sindhu *, N. Sood, V. Puri and S. Arora
Department of Pharmacognosy and Natural Products, Chitkara College of Pharmacy, Chitkara University, Patiala, Punjab, India.
29 September, 2016
28 November, 2016
01 December, 2016
01 April, 2017