VERMICIDAL ACTIVITY OF MILLETTIA PACHYCARPA ON THE NEMATODE, HETERAKIS GALLINARUMAbstract
The stem and root barks, leaves and seeds of Millettia pachycarpa Benth. are used for various medicinal purposes in Chinese and Mizo traditional practices. The plant extract reportedly showed potent vermicidal activity on cestodes. The ethanol extract of the root bark was tested against the poultry nematode, Heterakis gallinarum Schrank. In vitro treatment at 37±1°C revealed that a serial dose of the plant extract caused dose-dependent vermicidal effect on the worm (significant efficacy at P<0.05), except at the lowest dose (i.e. 5 mg/mL). A broad-spectrum drug albendazole also exhibited similar effect but with higher potency at all doses applied. The nematode treated with 80 mg/mL of the plant extract caused apparent destruction on the morphological structure, mostly of severe distortion in the cuticular organization throughout the body topography. Collapse of the lips and contraction of the body proper with prominent folding of the cuticle at the cephalic region were clearly discernible. At the posterior end were also extensive disintegration of the cuticle along with shrivelled cloacal mount and caudal papillae.
Department of Zoology, Pachhunga University College, Mizoram University, Aizawl 796001, Mizoram, India
27 May, 2011
24 August, 2011
29 August, 2011
01 September, 2011