VOLTAMMETRIC DETERMINATION OF OLOPATADINE HYDROCHLORIDE IN BULK DRUG FORM AND PHARMACEUTICAL FORMULATIONS
AbstractThe voltammetric behavior of olopatadine was investigated at hanging mercury drop electrode using cyclic voltammetry and differential pulse voltammetry. The drug under study exhibited a single, well-defined reduction peak owing to the reduction of carbon-carbon double bond. The electrode and reaction conditions which yielded maximum peak current were established using differential pulse voltammetry. A linear relationship was observed between the peak current and the concentration of olopatadine over the range 1.0 x10-8 M to 4.0 x10-7 M. The limits of detection and limits of quantitation were found to be 1.92ng/mL and 6.34ng/mL respectively. The proposed method was successfully applied for the determination of olopatadine in pharmaceutical formulations without interference from excipients.
Article Information
19
2517-2521
457KB
1022
English
IJPSR
N.Y. Sreedhar*, A. Sreenivasulu, M. Sunil Kumar and M. Nagaraju
Department of Chemistry, Sri Venkateswara University, Tirupati-517502, Andhra Pradesh, India
sreedhar_ny@rediffmail.com
29 March, 2012
07 May, 2012
21 July, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(8).2517-21
01 August, 2012
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