WOUND HEALING ACTIVITY OF SAMBUCUS EBULUSAbstract
This study aimed to evaluation of healing potential of Sambucus ebulus in full-thickness wound model in rats. A dorsal skin wound was created in rats. The 5% ointment applied to the wound area once a day for 12 days. Healing process was compared histologically between the groups. Parameters of wound healing were evaluated in the wound area. Extract improved wound contraction and closure. Histopathology study certified an organization of wound tissues. Extract reduced the number of inflammatory cells, increased wound-healing rate, epithelialization and significantly improved collagen formation. Granulation tissue formation was more organized when compared with control groups. S. ebulus showed positive effects on wound healing process and improved healing wounds.
D. N. Zarrin Ghabaee, Md. Ali Ebrahimzadeh, J. Akbari and F. Talebpour Amiri *
Anatomy Department, Mazandaran University of Medical Sciences, Sari, Iran
06 July, 2016
17 August, 2016
02 September, 2016
01 January, 2017