WOUND HEALING ACTIVITY OF URSOLIC ACID STEAROYL GLUCOSIDE (UASG) ISOLATED FROM LANTANA CAMARA L.Abstract
Lantana camara L. is regarded as a notorious weed and has found several practices in folk medicine in many parts of the world. Leaves of Lantana camara L. is traditionally used for cuts, swellings, and burns for their healing property. The leaves are found to contain various chemical constituents such as monoterpenes, sesquiterpenes, triterpenes, and glycosides. In the present study, Ursolic acid stearoyl glucoside (UASG) isolated from Lantana camara L. (100 mg/kg/day) was evaluated for its wound healing activity in albino rats using excision and incision wound models. UASG treated animals exhibited significant (P<0.01 and P<0.001) reduction in wound area when compared to controls. UASG treated wounds are found to epithelize faster as compared to controls. Significant (p<0.01) increase in granuloma breaking strength was observed when compared with the control group. Histological section of the granuloma tissue of control animal showing lesser collagen formation indicated incomplete healing of the wound compared to UASG treated animals where complete epithelialization and increased collagen deposition occurred. The UASG showed significant wound healing activity, and the effect was comparatively evaluated with the standard skin ointment Framycetin Sulphate.
M. Pravez and A. K. Patel *
Molecular Microbiology Laboratory, Department of Biotechnology, IIT Roorkee, Uttarakhand, India.
02 April 2014
18 May 2014
17 July 2014
01 October 2014