WOUND HEALING POTENTIAL OF CARALLUMA ADSCENDENSAbstract
The purpose of this current investigation was for screening the wound healing potential of Ethanolic extract of Caralluma adscendens (EECA) whole plant. Caralluma adscendens (Apocynaceae), a common medicinal plant in traditional Indian medicine. Mentions in folk medicine and existing data raised an outlook on this plant for evaluating wound healing potential. Ethanolic extract of Caralluma adscendens (EECA) has been examined for its wound healing activity by utilizing couple of wound models in rats: (i) excision wound model and (ii) incision wound model following application of standard or extract topically. Animals have been categorized into 4 groups with six in every group. Group I left untreated, Group II received soframycin skin cream as standard, Group III and IV received 100mg and 200mg of Ethanolic extract of Caralluma adscendens (EECA) whole plant. Results obtained upon treatment with the plant extract groups shown activity close to standard drug activity, Soframycin, in terms of wound contraction ability, time taken for wound closure and tensile strength. 200mg of plant extract has produced better wound healing ability after comparing to other dose. The obtained results notified that Caralluma adscendens swifts the wound healing process by reducing wound’s surface area and enhancing wound’s tensile strength.
Divya Yada *, Chaitnya Aindla and Uma Bandaru
Mall Reddy College of Pharmacy, Osmania University, Maismmaguda, Dhulapally, Secunderabad, Hyderabad, Telangana, India.
18 June 2023
17 August 2023
22 November 2023
01 February 2024