ZINGIBER OFFICINALE EFFECT ON HELICOBACTER PYLORI INFECTION IN HUMAN; A SYSTEMATIC REVIEWAbstract
Helicobacter pylori (HP) as a non-invasive microbe, has been cloned in the stomach. The most important side effects of HP are inflammation, peptic ulcer (PU) and gastric cancer (GC). Control of inflammation, leads to preventing other HP side effects and antibiotic resistance, therefore it is important to use of natural anti-inflammatory compounds. In present study, review the effect of Zingiber officinale (Z. officinale) in controlling side effects of HP in human. Related articles were collected in Google Scholar, Pub Med, Science direct, Scientific Information Database and Scopus. For this purpose, using the terms pylori, Zingiber officinale and Ginger in the title of the all articles published to 2020. Based on search results, were absorbed 15 articles in Google Scholar, 10 articles in Pub Med, 1 articles in Science direct, 1 article in Scientific Information Database and 13 articles in Scopus. After removing the same articles, protocols and no English language articles, finally reviewed, 8 English-language articles and 1 Farsi language article. Regard to long-term treatment of HP and the multiple side effects of routine therapy and possible formation of antibiotic-resistant strains, it’s necessary to use natural drugs with less side effects. The Z. officinale effects on HP such prevention, inhibitory proliferation and control of the side effects of HP colonization, and so economic efficiency and easy accessibility, have been identified as an appropriate candidate for treatment and prevention and of HP infection.
V. Mirzaee, A. Jafarzadeh, A. Tahmasebi and S. Jalalpour *
Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
18 October 2019
04 February 2020
04 March 2020
01 July 2020