Posted by admin on Dec 31, 2020 in |
The present study deals with the PHB made cast film with different plant and algal formulations. Its biocompatibility was tested in-vitro and in-vivo. The anti-inflammatory activity was higher in F4 and F5, close to the standard Diclofenac. The F7 and F8 exhibited moderate cytotoxicity, and formulation F2 exhibited low cytotoxicity. The maximum zone of inhibition was exhibited in F5 followed by F4 against skin pathogens. The overall results of antioxidant activity indicated that F4, F5, and F8 have good antioxidant properties. Percentage (%) of wound contraction at the 10th day of control was 16.9% and PHB alone was 21.3%. F5 and F3 showed higher activity with 51.7 and 49.7%, respectively. The self-healing potential was found to be 35.6%, but PHB was able to cure additional 5% (40.5) on 16th day. F5, F3, and F4 showed high activity of 81.5, 80.1, and 79.9, respectively. The in-vitro and in-vivo studies showed that the Centella asiatica and Padina tetrastromatica with PHB has an effective activity towards antimicrobial, antioxidant, and wound healing activity....
Read More
Posted by admin on Nov 30, 2020 in |
Medicinal plants are widely used to treat disease in non-industrialized societies for not being far cheaper than modern medicines. In this study, five types of medicinal plants viz., Glycyrrhiza glabra, Aegle marmelos, Centella asiatica, Cinnamomum verum, Cynodon dactylon were collected from Alwarkurichi, Tirunelveli District, Tamil Nadu, and extracts were prepared using various solvents such as methanol, ethanol, chloroform, diethyl ether, benzene, and water. These extracts were checked for antibacterial activity against Staphylococcus aureus isolated from a hospital environment. On the basis of antibacterial activity, three plants viz., Glycyrrhiza glabra, Aegle marmelos, and Centella asiatica were chosen for further research in which the ethanolic extract of Glycyrrhiza glabra rendered higher activity against Staphylococcus aureus. Thin Layer Chromatography of the plant extract of Glycyrrhiza glabra was carried out, which showed the development of four bands of which the first three bands rendered higher sensitivity against Staphylococcus aureus. The eluted bands from TLC were visualized under the UV-Spectrophotometer to monitor the absorbance of the eluted three bands in the wavelength spectrum ranging...
Read More
Posted by admin on Oct 31, 2020 in |
The imbalance between aggressive (pepsin, Hydrochloric acid) and protective elements (bicarbonate and mucosa) in the inner lining of the stomach lead to the formation of peptic ulcers. The presence of Body fluids, mucosal hydrophobicity, fast epithelial cell recharging, and rich mucosal blood flow is involved in mucosal protection of the Stomach. Prostaglandins E2 and I2 are the predominant prostaglandins which synthesized by the gastric mucosa and known to hinder the emission of gastric acid and stimulate the discharge of body fluid and bicarbonate. The treatment of peptic ulcers can either be achieved with declination in aggressive elements or elevation of mucosal resistance in the stomach and duodenum with cytoprotective agents. In this review, 30 herbal medicinal plants have been discussed along with its respective extracts; these are Bauhinea veriegata, Euphorbia umbellata, Azadirachta indica, Centella asiatica, Indigo feratinctoria, Mangofera indica, Moringa oleifera, Mimosa pudica, Aegle marmelos, Lawsonia inermis, Tephrosia purpuria, Plantago lanceolata, Solanum nigrum, Annonas quamosa, Ocimum sanctum, Morus alba, Pinusrox burghi, Allium sativum, Hibiscus cannabinus, Emblica officinalis, Curcuma longa,...
Read More
Posted by admin on Nov 1, 2012 in |
Alzheimer’s disease (AD) is characterized by the abnormal aggregation of amyloid ß (Aß) peptide into insoluble fibrils called amyloid plaques. Preventing this process of fibrillization may offer effective therapy for treatment of AD. The aim of the present study is to investigate the effect of methanolic extracts of 13 plant species which are known to be brain boosters in Ayurvedic system of medicine. Our study addressed the influence of these extracts on (i) prevention of aggregation of Aß and (ii) dissociation of preformed Aß fibrils. The aggregation status was monitored by thioflavin T fluorescence assay. The results showed that extracts from Bacopa monneria, Centella asiatica, Convolvulus pluricaulis, Withania sominfera, Nardostachys jatamansi and Glycirrhiza glabra exhibited promising activity by preventing Aß fibril formation/ retention thus identifying Aß as the molecular target for their action. These findings prompt further studies to isolate the active ingredients from these extracts to ultimately determine their therapeutic potential in AD...
Read More
Posted by admin on Mar 1, 2012 in |
Centella asiatica is a medicinal plant. It is severely affected by leaf spot disease caused by a harmful, antibiotic resistant phyto pathogen Xanthomonas campestris pv. centellae (X. c. pv. c). Farmers used synthetic pesticides to control the disease. When pesticides are applied to control this pathogen, pesticides may cause environmental hazards and health problems in man. But traditionally plants are used to prevent or control the plant diseases in agriculture. It is an eco- friendly, biocontrol, traditional method. Hence the aim of the present study is to control the pathogen in biocontrol method by screening the phytochemicals and antibacterial activity of petroleum ether, chloroform, benzene, methanol and aqueous extracts of fronds of five ferns (Pteridophytes) Adiantum caudatum, Angiopteris evecta, Pteris confusa, Pteris argyraea and Lygodium microphyllum against X. c. pv. c. The methanol extracts of all the ferns gave successful result against the tested bacteria. Phytochemical analysis of all the extracts revealed that antibacterial activity is due to the presence of alkaloids, flavonoids and phenolic compounds. According to the...
Read More
