Posted by admin on Dec 31, 2021 in |
In organic chemistry, the largest families of organic compounds belong in the heterocyclic compounds. In our daily life, the importance of heterocyclic compounds is very essential. It has a broad range of applications in medicinal chemistry. Benzotriazole is a bicyclic heterocyclic system consisting of three nitrogen atoms and a fused benzene ring, shows wide range of biological and pharmacological activities. Benzotriazole has been a matter of discussion among the scientific community due to its potential characteristics and touched areas such as medicinal, pharmacological, industrial, etc. Benzotriazole derivatives have shown several pharmacological activities, which are antimicrobial activity, anti-inflammatory, analgesic activity, anticancer, antifungal, antibacterial, anticancer, anthelmintic, antidepressant, antioxidative, antitubercular, antiviral, anticorrosive, plant growth inhibitor, anti-inflammatory,...
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Posted by admin on Dec 31, 2021 in |
Euphorbia hirta Linn. (Euphorbiaceae), commonly known as ‘Dudhy’ is an annual medicinal herb of Kumaun Himalaya Uttarakhand. It is an invasive plant used in conventional medicine to treat various diseases such as gastrointestinal disorders, respiratory system disorders, and asthma. The present review is designed with the aim to compile updated information on E. hirta including its medicinal uses, phytochemicals, as well as biological activities. Qualitative and quantitative phytochemical studies on E. hirta revealed the presence of various chemical compounds in which flavonoids, terpenoids and phenols are the major constituents. These monomeric compounds and crude extracts from E. hirta have also been screened for pharmacological activities in-vivo and in-vitro. Different parts of the plant have interesting antimicrobial, antioxidant, antidiabetic, and antitumor properties. Some traditional uses of this plant, such as in gastrointestinal disorder, bronchitis, and in asthma, also indicated its high medicinal potentiality. E. hirta has been proved a valuable medicinal plant for the tribal people living in the rural region of Kumaun Himalaya. The crude hydro-alcoholic extract of E....
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Posted by admin on Dec 31, 2021 in |
A new series of Schiff’s base compounds were synthesized by condensation of 1-(4-amino-4 phenyl) 3-phenyl triazene-1-ol) and substituted aldehyde and gave high yields of target compounds. Antimicrobial activity of compounds has been tested against bacterial and fungal species, namely gram-positive bacteria as S. aureus and S. pyogenes, gram-negative bacteria as E. coli and P. aeruginosa, and fungal species C. albicans and A. clavatus are selected based on their clinical and pharmacological importance. Bacterial and fungal tests were performed under the same conditions using Cefixime and Griseofulvin as standard drugs. It has been found that synthesized Schiff’s base has shown efficient antibacterial and anti-fungal activities. Thus they can be revealed as potent antimicrobial compounds. They are widely used for industrial purposes and also exhibit a broad range of biological activities. The structures of synthesized compounds were confirmed by TLC, melting point, Infrared spectroscopy, and proton nuclear magnetic resonance spectroscopy (1HNMR)...
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Posted by admin on Nov 30, 2021 in |
The study was designed to optimize cultural conditions for enhanced production of bioactive compounds by Streptomyces olivo-verticillatus VLK-15 isolated from mangrove ecosystem of South Coast of Andhra Pradesh, India. The soil dilution plate technique was employed for the isolation of actinobacteria using starch-casein agar (ISP-6) medium. The potent strain was identified as Streptomyces olivoverticillatus VLK-15 based on polyphasic taxonomy. The productivity of the strain was enhanced by amending the medium (ISP-2) with mannitol (0.5%), peptone (0.5%), and K2HPO4 (0.05%) adjusted to pH 7.0 and incubated with the culture at 30ºC for ninety-six hours. The secondary metabolites produced under optimized conditions exhibited high antimicrobial activity against Gram-positive and Gram-negative bacteria as well as fungi. Hence, it could be a possible source for novel and potential antimicrobial...
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Posted by admin on Nov 30, 2021 in |
Azetidinones (Azetidin-2-ones), more commonly known as β-lactams, are well-known heterocyclic moieties among the medicinal compounds mainly because of their diverse pharmacological activities such as antimicrobial, anti-inflammatory, anticonvulsant, anti-HIV, anti-parkinsonian, antidiabetic and antitubercular activities. Various com-parative studies of current azetidinone derivatives show an alarming increase in the bacterial resistance to the β-lactam nucleus may be due to irrational usage, which unfortunately led to less therapeutic usage. Hence new hybrids of Azetidinones with other drugs containing different heterocyclic rings found to possess broad-spectrum efficacy against various types of bacteria with β-lactamase inhibition to find great scope for future needs. This concept of hybrid molecules of different heterocyclic drugs would be a cost-effective and time-saving experiment in the process of drug discovery and development. In today’s world of diseases and expensive drugs which are not affordable for countries like India, this attempt would be noon. Hence this review is an attempt to focus on the possible hybrid molecules of Azetidinones with other heterocyclic drugs for various...
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