Posted by admin on Nov 30, 2021 in |
Euphorbia hirta Linn. (Euphorbiaceae), commonly known as ‘Dudhy’ is an annual medicinal herb of Kumaun Himalaya Uttarakhand. It is an invasive plant used in conventional medicine to treat various diseases such as gastrointestinal disorders, respiratory system disorders, and asthma. The present review is designed to compile updated information on E. hirta, including its medicinal uses, phytochemicals, as well as biological activities. Qualitative and quantitative phytochemical studies on E. hirta revealed the presence of various chemical compounds in which flavonoids, terpenoids, and phenols are the major constituents. These monomeric compounds and crude extracts from E. hirta have also been screened for pharmacological activities in-vivo and in-vitro. Different parts of the plant have interesting antimicrobial, antioxidant, antidiabetic, and antitumor properties. Some traditional uses of this plant, such as in gastrointestinal disorders, bronchitis, and asthma, also indicated its high medicinal potentiality. E. hirta has been proved a valuable medicinal plant for the tribal people living in the rural region of Kumaun Himalaya. The crude hydroalcoholic extract of E. hirta has more pharmacological...
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Posted by admin on Nov 30, 2021 in |
The present study evaluated the antimicrobial and cytotoxic activities of chloroform, hexane methanol, and petroleum ether extracts of Plumbago zeylanica (PEC, PEH, PEM, and PEP). Antimicrobial activities of the extracts were evaluated against gram-positive bacteria (Staphylococcus aureus-ATCC 6538 and Bacillus cereus-NCIM 2155) and gram-negative bacteria (E. coli-ATCC 8739) along with cytotoxicity activity against cervix carcinoma cell lines (HeLa and SiHa cell lines). Out of the four extracts tested, PEM and PEC extracts showed significantly high value of zone of inhibition against tested bacteria. PEM showed zone of inhibition of 10 mm, 13mm and 8 mm in ATCC 6538, NCIM 2155 and ATCC 8739, respectively. On the other hand, chloroform extract showed a zone of inhibition of 8mm, 10mm and 7 mm in ATCC 6538, NCIM 2155 and ATCC 8739, respectively. The four extracts PEC, PEH, PEM, and PEP showed a significant cytotoxicity activity with IC50 concentration at 238.93ug/ml, 694.44ug/ml, 580.40ug/ml and 593.04ug/ml against the HeLa Cell line and 142.71ug/ml, 547.16ug/ml, 448.04ug/ml and 424.27ug/ml respectively against the SiHa Cell line...
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Posted by admin on Nov 30, 2021 in |
Usage of medicinal plants for the treatment of various diseases had been started from 1500 BC onwards. Loss of cognition is one of the age-related mental problems and a characteristic symptom of neurodegenerative disorders like Alzheimer’s. Various natural drugs are used for treatment of Alzheimer’s and Parkinsonism, but Available drugs provide symptomatic treatment with known side effects. So the present study is aimed to evaluate anti-amnesic activities of ethanolic flower extract of Ixora coccinea on mouse model as an attempt to search for new compounds against Alzheimer’s disease-related memory impairment. Ixora coccinea is a common flowering shrub native to Southern India and Sri Lanka. Traditionally it is used as hepatoprotective, antimicrobial, anti-oxidant, anti-nociceptive, anti-mitotic and anti-inflammatory activities. Decoction of roots was used for nausea, hiccups, and anorexia. Numerous activities were reported on the entire plant and various parts of the plant like root, leaf, and flower .The anti-amnesic activity was screened by the stair case method and elevated plus maze method. The staircase method has been widely used in...
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Posted by admin on Nov 30, 2021 in |
Jatropha gossypiifolia Linn. (Euphorbiaceae) is an ornamental shrub extensively used in traditional medicine for various ailments. In view of its potential medicinal properties, an attempt has been undertaken to devise an efficient protocol for in-vitro propagation from the internodes explants of J. gossypiifolia for a rapid and large-scale production as well as to study the phytochemical composition by gas chromatography and mass spectrometry (GC-MS). Further, the petroleum ether and ethyl acetate extracts of callus tissue were subjected to thin-layer chromatography (TLC) as well as for synthesizing silver and gold nanoparticles. The five bands resolved by TLC chromatogram were characterized by Fourier Transform Infrared Spectroscopy (FT-IR) and screened for antimicrobial and antioxidant activities. Internode region of the one-year-old plant was used as explants. Internodal explants are cultured on Murashige and Skoog (MS) medium containing Naphthalene acetic acid (NAA) and 2,4-Dichlorophenoxy acetic acid (2,4-D) both at a concentration of 1.0 mg/L-1 induced the formation of callus between 14-18 days. This combination produced mature cream-colored calli by day 35. Explants growing on...
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Posted by admin on Oct 31, 2021 in |
Actino bacterium Streptomyces sp. NLKPB45, which was isolated from mangrove soil sediments of Nellore coastal regions of Andhra Pradesh, India, was used in shake-flask fermentation to explore the different carbon and nitrogen substrates for antimicrobial crude compound. Careful experimentation of ranging each variable in the fermentation medium found that glucose and peptone as preferred carbon and nitrogen sources at 1% (w/v) concentration each, at pH of 7 and 28 °C incubation temperature for 8 days of incubation time. Response surface methodology-based statistical optimization of the process variables with their interconnection was analyzed using a central composite design. A second-order quadratic polynomial equation yielded a complacent fit for experimental with respect to crude compound concentration. Analysis of variance statistics showed that significant-high R2 value for model and adjusted and predicted; R2 values were also shown decent agreement with observed and predicted results. The results have confirmed very good interaction among five process variables at optimized values of 7.51318 pH, 28.734 °C incubation temperature, 8.18409 days incubation time, 1.05185 g/L glucose...
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