Posted by admin on Jun 30, 2021 in |
Bacterial infections are one of the prominent causes of health problems and mortalities around the world. Medicinal plants are a rich source of antimicrobial agents and provide a safer and cost-effective way of treating bacterial infections. The objective of the present investigation was to evaluate the anti-bacterial potential of petroleum ether and methanol extracts of Anacardium occidentale L. leaf. The anti-bacterial potential of A. occidentale L. leaf was tested against gastrointestinal tract infection-causing bacteria such as Escherichia coli, Shigella flexneri, Enterococcus faecalis, Vibrio cholariae, Staphylococcus aureus, Klebsiella pneumoniae, and Salmonella typhi by using the agar well diffusion method. Streptomycin was taken as the reference antibiotic. The results indicated that petroleum ether extract of A. occidentale L. exhibited the highest zone of inhibition against Shigella flexneri (26±0.75) and least against Staphylococcus aureus (11±1.32). In contrast, methanolic extract exhibited the highest zone of inhibition on Vibrio cholariae (20±1.41) and least against Escherichia coli (11±0.21). The preliminary phytochemical analysis revealed the presence of alkaloids, glycosides, tannins and polyphenolic compounds, flavonoids, saponins, steroids,...
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Posted by admin on Jun 30, 2021 in |
Background: Wound infection occurs when one or more organisms invade the wound. Nosocomial infections are the most common hospital acquired infections responsible for mortality and morbidity. Multidrug resistance against bacterial strains is the most serious emerging situation in worldwide, warranting the search for other alternatives. In this regard Pentabark kashaya was developed which contains ingredients possessing antimicrobial, anti inflammatory, and wound healing activity. Materials and Methods: Antibacterial activity of Pentabarkkashaya (PK) was determined against three predominant bacterial strains one gram positive and two gram negative strain Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. The sensitivity of the organisms were tested by both the agar well method and broth dilution method (MIC) and it was compared with the antibacterial activity of provide iodine solution 5%. Result: Pentabark kashaya showed antibacterial activity against all the test pathogens in both agar well and broth dilution method. The highest antimicrobial activity was observed against Escherichia coli and Pseudomonas aeruginosa in agar well diffusion method showed the inhibitory zone of 14 mm in both...
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Posted by admin on May 31, 2021 in |
Nanotechnology can be applied to deliver and protect antioxidants in order to control the oxidative stress phenomena in several chronic pathologies. Chitosan (CS) and its carboxymethyl derivatives are smart biopolymers that are non-toxic, biocompatible, and biodegradable, and, hence, suitable for various biomedical applications, such as drug delivery gene therapy and tissue engineering. Vitis vinifera (VV) seeds are the major chemotherapeutic agent with antioxidant, anti-inflammatory, antiproliferative, anticancer, and antimicrobial effects. However, the potential of these leaves as a chemotherapeutic agent is limited by their hydrophobicity and poor bioavailability. The chitosan tripolyphosphate (CS/TPP) nanoparticles have been used in this study as an alternative to encapsulate bioactive flavonoids from ethanolic extract of Vitis vinifera seeds. The Vitis vinifera seeds extract-loaded CS (CS-VVE) nanoparticles were characterized using FT-IR. The Zeta sizer and zeta potential confirmed that the particle has 216nm and 50.3mV. This study also found that the CS-VVE NPs shown anticancer activity in human colon cancer cell lines should be explored further for Cytotoxicity studies using MTT assay and tested drug-induced apoptotic...
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Posted by admin on May 31, 2021 in |
Tea tree oil, an essential oil, has claims for analgesic, antimicrobial, antiseptic, and anti-inflammatory activity. Its complex composition is governed by ISO 4730:2017. It is extensively used in skin and hair care cosmeceuticals, often in combination with neem seed oil. Neem seed oil has potent antimicrobial, skin rejuvenating, and conditioning action attributed to the presence of micro constituents and complex lipid composition of triglycerides, diglycerides, and monoglycerides of both saturated and unsaturated fatty acids. Although few methods are available for estimation of individual oils, simple spectrophotometric methods suitable for routine determination of either oil or for simultaneous estimation of both the oils are not reported. A novel, simple, validated UV spectrophotometric method for simultaneous estimation of tea tree oil and neem seed oil in bulk and cosmeceutical formulation has been developed after optimization and validation of UV spectrophotometric method for individual estimation of oils. The method relies on the measurement of absorbance at 267nm and 284nm, λmax of tea tree oil, and neem seed oil, respectively. Linearity is established...
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Posted by admin on Apr 30, 2021 in |
The present study aimed to determine the phytochemical components of the leaf extracts of A. malabarica, antimicrobial, antioxidant activities and GC-MS analysis. The leaves extracts have folklore and traditional applications in India. The polar and non-polar solvents extracts such as methanol, ethyl acetate, chloroform, hexane and water were used for various phytochemical analysis proved the existence of flavonoids, glycosides, phenols, 3terpenoids, tannins and alkaloids. Similarly, five different extracts of A. malabarica were tested for the antibacterial activities against five human pathogens. The present results revealed that, the different solvent extracts showed maximum zone of inhibition against all the tested strains. The plant extract was highly effective against E. coli and E. aerogenes. In addition, the extracts noted promising GC-MS analysis showed the presence of bioactive...
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