Posted by admin on Sep 30, 2020 in |
Adaptation of marine actinobacteria to extreme climatic conditions such as high salinity, high pressure and high temperature has modified their physiological conditions to survive and elaborate novel bioactive metabolites. Among the different actinobacterial strains isolated from coastal regions of Guntur District, Andhra Pradesh, India, one potent strain with broad-spectrum antagonistic activity was found and identified as Streptomyces rectiverticillatus VJMS-8. Attempts were made to optimize the cultural parameters for an enhanced yield of antimicrobial metabolite production. Production of bioactive metabolites by the strain was high in tryptone yeast extract dextrose broth as compared to the other media tested. The strain utilized galactose and tryptone as good carbon and nitrogen sources for the elaboration of bioactive metabolites. The optimum temperature and pH for bioactive metabolite production by the strain were recorded as 35 °C and 7.0, respectively. NaCl @ 5% supported high pro-duction of bioactive metabolites. The secondary metabolites produced by the strain grown under optimal conditions exhibited high antagonistic activity against a variety of gram-positive and gram-negative bacteria as well...
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Posted by admin on Sep 30, 2020 in |
Merremia emarginata is a creeping herb, rooting at nodes, and commonly used in folk medicine. The current study was undertaken with the aim of preliminary phytochemical analyses, evaluation of antimicrobial activity, and antioxidant activity by methanol and aqueous extracts of leaves of Merremia emarginata. The extracts were subjected to preliminary phytochemical analyses; Antibacterial activities against nine bacterial strains were done by using agar – well diffusion method and free radical DPPH antioxidant activity. Preliminary phytochemical analyses were done by using standard phytochemical methods that showed the presence of Carbohydrates, reducing sugars, phytosterols, fixed oils, saponins, phenolic compounds and flavonoids. Based on the results of phytochemical analyses, methanol and aqueous extracts of the plant were chosen for antibacterial studies. Methanolic extract of leaves showed the highest antibacterial activity followed by the aqueous extract. The present study indicates that the leaves of Merremia emarginata possess antibacterial activity and found effective against eight bacterial cultures. Antioxidant activity of the DPPH assay showed that extracts exhibit the scavenging effect of various...
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Posted by admin on Sep 30, 2020 in |
The facts like developing resistance in bacterial pathogens against conventional antibiotics, emergence of new infectious agents etc. have been leading the scientists to tedious research activities to find out antimicrobial drugs with novel modes of action. Among the multidrug-resistant (MDR) bacterial species that pose threat to human life, the IDSA has identified a group pathogens known as ESKAPE pathogens which show extensive drug resistance through a wide range of mechanisms. Silver nanoparticles (AgNPs) have been identified as very effective and to avoid the chemical contamination in preparation of them, green synthesis is being used. In the present study, AgNPs using Picrorhiza kurroa Royle ex Benth were synthesized using reduction method. The green synthesized AgNPs were characterized by UV–Vis, DLS-zeta potential and FESEM analysis. Anti-ESKAPE activity of the synthesized nanoparticles was also performed. FESEM studies revealed that the nanoparticles were spherical and nanosize in shape. The UV–Vis spectral studies confirmed the surface plasmon resonance of green-synthesized silver nanoparticles. The particle size was found to be 267 nm and the stability...
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Posted by admin on Sep 30, 2020 in |
Angina Pectoris is the medical term for chest pain or discomfort due to coronary heart disease. The drawback of the marketed formulation is required repeated administration of the drug due to low bioavailability. Therefore, it utilized a nanotechnology technique for prevention of drawback of marketed formulation. Polymeric nanoparticles have been in preferential list when it comes to nano-drug delivery via oral route. Recent advances in lipid-reducing treatment, statins clinical research suggests that antimicrobial therapy is important to continue reducing cardiovascular events, beyond lipid-reducing therapy. A potential therapeutic choice for the residual risk is to intervene directly in the inflammatory process through a drug delivery system based on the nanotechnologies. Different nano-sized materials, including micelles, liposomes, polymer nano-particles, dendrimers, carbon nanotubes, and metal nanoparticles, are currently developed as by nanotechnology. It is a viable strategy since the inflammatory environment enhances the integration of nano-sized materials into a mononuclear phagocytic process. We have recently developed a polymeric nano pharmaceutical statin in order to optimize its anti-inflammatory properties. In the present review,...
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Posted by admin on Aug 31, 2020 in |
Benzimidazole, a fused heterocyclic moiety containing benzene and imidazole, has gained considerable attention in the field of medicinal chemistry due to its wide array of pharmacological activities. Be it as a antifungal, anticancer agent, proton pump inhibitors, anthelmintic, anti-microbial, analgesic, it has become an intrinsic part of the pharmaceutical world. The presence of Nitrogen in its heterocyclic ring has made it a more biologically active pharmaceutical agent. The fact that benzimidazole residue is a constituent of vitamin B12 supports its potential use in therapeutics. Benzimidazole derivatives are the structural isosters of naturally occurring nucleotides such as purine, allow them to interact effectively with the biopolymers of the living system such as proteins, enzymes, and receptors. Benzimidazoles exhibit significant activity as a potential anti-tumour agent, smooth muscle cell proliferation inhibitors, a treatment for intestinal cystitis, and in a diverse area of medicinal chemistry. The synthesis of novel benzimidazole derivatives remains as the main focus of medicinal research. This current review covers the chemistry and significance of benzimidazole and its derivatives,...
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