Posted by admin on Dec 31, 2019 in |
Gmelina arborea Roxb. belongs to the Verbenaceae family, commonly known as Gambhar. It is distributed throughout India, Ceylon, Malayan and Philippine Islands. Its roots have anthelmintic properties. Its flowers are useful in the treatment of leprosy and blood diseases. Its fruit has diuretic properties and aphrodisiac. It is also used in anemia leprosy and vaginal discharges. Leaves have shown analgesic, antimicrobial, and anti-diabetic activities. A new flavone glycosides 5, 7.4ʹ-trihydroxy-8, 3ʹ-dimethoxyflavone- 4ʹ-O-β-D-glucopyranosyl- 7-O-β-D-xylopyranosyl (1→2)-α-L-rhamnopyranoside(A) along with two known compounds Luteolin (B) and Apigenin (C) were isolated from ethanolic extract of the stem parts of the plant. The characterization and structural elucidation of these compounds were carried out by various color reactions, chemical degradation, and spectral analysis. Antioxidant activity of compound A was evaluated by 1, 1-diphenyl-2-pycrylhydrazyl (DPPH) assay system which has shown a significant radical scavenging...
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Posted by admin on Dec 31, 2019 in |
Secondary metabolites not only play a vital role in plant defense but also had shown various medicinal properties which provide a scientific base for using herbs and different plants as alternative medicines that were used by ancient communities. Many of the drugs today are simple synthetic modifications of the natural compounds. The developing commercial requirements of secondary metabolites in recent years has resulted in a great interest in secondary metabolism. Different strategies have been studied with the objective of improving the production of secondary metabolites. Many studies proved the role of plant growth regulators in the accumulation and production of many of these active and therapeutic compounds. Short term experiment was carried out to investigate the response of Catharanthus roseus L. plant to the foliar spray of GA3, IAA and 6-bezylaminopurin at (0, 30, 60, 90 ppm) concentrations during the blooming stage. Three parameters were studied, phenols content, alkaloids content and the antioxidant activity in leaves extracts of this plant. Results showed there were significant increments in all studied...
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Posted by admin on Dec 31, 2019 in |
Introduction: Cutaneous adverse drug reactions (CADRs) associated with significant morbidity and mortality are probably the most frequent of all manifestations of drug sensitivity. Material and Methods: It was a prospective observational study where newly diagnosed patients with ADRs reporting to OPD of Dermatology, K.G.M.U, Lucknow and satisfying inclusion criteria were enrolled. The various study tools used were the suspected ADR reporting form (CDSCO), Naranjo’s causality scale, Modified Hartwig and Siegel severity scale and Dermatology Life Quality Index. Results: In a total of 124 patients recorded with CADRs, males (60.5%) were found more affected than females (39.5%). The most common age group found was 21-30 yrs (36.3%) followed by 31-40 yrs (25.8%) with a mean age ± SD 35.88 ± 13.87 range (18-78) years. The most common clinical pattern observed was Fixed Drug Eruption (FDE) (49.2%) followed by maculopapular rash (MPR) (36.3%). The incidence of Severe CADRs (SCADR) was 8.06%. Antimicrobial (50.8%) followed by unknown (17.7%), combinations (14.5%) and anti-epileptics (8.9%) were the most common drug groups suspected. On the...
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Posted by admin on Dec 31, 2019 in |
The aim of this research was to perform phytochemical screening and evaluation of the pharmacological activities of Buchanania lanzan Spreng. leaves. Preliminary phytochemical screening revealed the presence of phytoconstituents like steroids, tannins, saponins, carbohydrates, alkaloids, and flavonoids. Three leaf extracts were prepared by using solvents e.g. chloroform, ethyl acetate, and ethanol. The antibacterial activity was evaluated by using the paper disc method against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The chloroform extract was found to be more effective against Pseudomonas aeruginosa with a zone of inhibition 20 mm as compared to the standard anti-biotic ampicillin with a zone of inhibition 20 mm. Antifungal activities were evaluated by well diffusion assay against Candida albicans, Aspergillus flavus, Aspergillus niger. The chloroform extract was found be more effective against Aspergillus flavus and Candida albicans with a zone of inhibition 22 mm and 20 mm respectively as compared to the standard antifungal ketoconazole with a zone of inhibition 22 mm. Antifungal activity against Aspergillus niger with zone of inhibition 22 mm was...
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Posted by admin on Dec 31, 2019 in |
The research herbal formulation prepared by mixing dried stem barks of Azadirachta indica A. Juss. and Saraca asoca Roxb. in equal amounts is standardized through pharmacognostic and phytochemical studies for assessing its efficacy in the treatment of leucorrhoea/vaginitis/ excessive white discharge. Pharmacognostical analysis revealed total ash value of 9.43% having 1.89% acid insoluble ash, 4.62 pH and 7.70% moisture content and presence of nitrogen and halogens. Flavonoids, tannins, carbohydrates, glycosides, saponins and fixed oils were found present in the hydro-alcoholic extracts. The results also showed a high concentration of flavonoids compounds (43.37 µg quercetin equivalent/mg) and high phenolic content (101.22 µg gallic acid equivalent/mg). UV-Visible spectroscopy scanning showed a prominent peak at 277 nm in the hydro-alcoholic extract. HPTLC analysis at 254 nm, 277 nm, and 330 nm indicated the presence of tannic acid, gallic acid, quercetin and catechol. Similarly, HPLC analysis at 277 nm suggested the presence of gallic acid, tannic acid and catechol. FTIR analysis exhibited the presence of N-H stretching, C-H stretching, N-H bending, N-O asymmetric...
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