Posted by admin on Feb 28, 2019 in |
The formulation and evaluation of toothpaste contain Aloe vera along with the combination of sodium chloride. Aloe vera shows a number of uses either internally or externally, and the number of uses also increases as the research going on. In this formulation, we tried to find out the antimicrobial activity of Aloe vera in toothpaste formulation, for the said purpose we use S. aureus culture. After designing the batches in software Design Expert® 10, the batches were formulated and evaluated. At the end of work, we found that the prepared toothpaste shows considerable zone of inhibition which concludes its antimicrobial activity. The formulation also shows sufficient foaming power for its cleansing action. The observed results were found to significant concerning the chosen cubic model in software Design Expert® 10. Thus from the collected results, we concluded that the toothpaste containing a combination of Aloe and sodium chloride possesses antimicrobial activity, but for its practical use its necessary to determine its effect on oral cavities and probable side effects after...
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Posted by admin on Feb 28, 2019 in |
This study reports the potential of Alternanthera sessilis leaves as antioxidant, antimicrobial, anti-inflammatory and anti-diabetic agent and also the characterization of a novel phytochemical from A. sessilis using bio-activity guided extraction. Antimicrobial property was studied against five bacterial pathogens, Escherichia coli (MTCC: 1687), Bacillus cereus (MTCC: 0430), Klebsiella pneumonia (MTCC: 7028), Staphylococcus aureus (MTCC: 3160), Proteus mirabilis (MTCC: 3310) and against two fungal pathogens, Aspergillus niger [MTCC 281] and Aspergillus flavus [MTCC 10938]. Petroleum ether extract of A. sessilis leaves demonstrated significant antimicrobial property and hence was further purified to identify its active phytochemicals. Silica-gel Column Chromatography followed by antimicrobial screening, lead to the identification of the active fraction, that was characterized by spectroscopic analyses. FT-IR, GC-MS and NMR (C13, and DEPT-45; 90; 135) analysis of the active fraction, characterized the phytochemical to be 3,3’-(propane-2, 2-diyl)-bis-(3,4,5,6,7,8-hexahydro-1H-isochromene) abbreviated as PDHC. To the best of knowledge, this is the first report of PDHC due to novelty in its chemical structure. In-silico molecular docking was performed for this identified compound to identify...
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Posted by admin on Feb 28, 2019 in |
Drug release properties from dosage forms can be modified by using many rate controlling polymers. Such controlled release properties from carrier systems are desirable since efficient drug delivery is achieved. The aim of the present study was to develop efficient chitosan nanoparticles loaded with rosmarinic acid (RA) and evaluate its drug release properties and wound healing efficiency in rats. Antimicrobial activity and wound healing effect of RA is well established and reported by many workers. Chitosan is also well known for possessing rate controlling properties. For proper application over wounds, the nanoparticles were incorporated into carbopol 940 hydrogel. A fourteen-hour in-vitro release study was carried out to evaluate the drug release efficiency and drug release kinetics of the nanoparticles. Other parameters evaluated were particle size, polydispersity index (PDI), zeta potential, morphology. Carbopol 940 hydrogel was evaluated for optimum viscosity (18.43 ± 1.7), swelling (250 ± 7.9) and spreadability (31 ± 1.5). The in-vivo study was carried out in three groups of animals, those treated with gel containing RA loaded...
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Posted by admin on Jan 31, 2019 in |
A new derivative of Guar gum, incorporated with 1, 3, 4-thiadiazole nucleus was synthesized by using a new green and efficient synthetic approach. Guar gum is a biodegradable polymer having numerous applications in various industries. Thiadiazole compounds are well known in the therapeutic world due to their pharmacological importance. The newly synthesized derivative was characterized by IR, H1 NMR, and mass spectrometry. Its antioxidant activity was determined by hydrogen peroxide scavenging activity. Its antimicrobial activity was also...
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Posted by admin on Jan 31, 2019 in |
This study aimed to introduce antibacterial nanofibers, produced by electrospinning as a novel technique in constructing nanostructured materials. In the electrospinning technique, a high voltage is applied to a polymer solution to overcome the surface tension. A charged polymer jet is ejected to a grounded electrode. As the solvent is evaporated, the electrospun fiber with diameter from micrometer to nanometer is formed. One of the most important features of electrospun nanofibers stated in this paper is their activity as effective carriers of antibacterial substances, which leads to the use of them in many fields such as food packaging, drug delivery, wound healing, filtration, and food sciences. An electrospun nanofiber containing antimicrobial agents indicates excellent antibacterial functions against a wide spectrum of bacteria and sustain the antibacterial activity over a long period. In general, several aspects of antibacterial nanofibers, including synthesize, applications, types of antibacterial agents combined with them such as essential oils, herbal bioactive components, metals, drugs, and peptides have been...
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