Posted by admin on Jun 30, 2019 in |
In the present investigation, the chalcone intermediates are synthesized by Claisen-Schmidt condensation reaction between acetanilide and appropriate aromatic aldehydes. Further, these chalcone intermediates were cyclized with phenylhydrazine in glacial acetic acid to give new pyrazolines derivatives using ultrasonic irradiation with higher yields in lesser time. All the synthesized derivatives are characterized by their TLC, Physical constant, FTIR, and 1H NMR. The Chalcone intermediates were screened for their antimicrobial activity while cyclized pyrazolines derivatives were screened in search of potential anti-inflammatory compounds. The compound 4c had shown good potential for anti-inflammatory...
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Posted by admin on Jun 30, 2019 in |
The emergence of antibiotic-multidrug resistant microorganisms is an essential issue in the health sector. Consequently, the exploration of new antimicrobial compounds from many promising resources is urgently required. Soft coral-associated bacteria are potential as antimicrobial compound producers. This study aims to get the best medium and fermentation conditions in the production of secondary metabolites having antibacterial activities and to identify antibacterial agents from a bacterium associated with soft coral. A soft coral sample was collected from Randayan Island, Indonesia, and was identified morphologically as Sarcophyton sp. One of the bacteria isolated from the Sarcophyton sp. showed antibacterial activities and identified as Bacillus sp. based on Bergey’s Manual of Determinative Bacteriology. The best antimicrobial activities of Bacillus sp. DA11 were carried out on medium 1/10 Zobell supplemented with 1% of glucose (1/10ZG) which were able to against all of the test bacteria except on a test fungus, C. albicans. The extract was prepared on medium 1/10ZG with liquid state fermentation without shaking showed the best condition to produce secondary metabolites...
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Posted by admin on Jun 30, 2019 in |
Benzothiazole derivatives have a wide interest because of their diverse biological activities and clinical use. This bicyclic compound consists of a fusion of benzene nucleus with a five-membered ring comprising nitrogen and sulphur atoms. It is a vital Pharmacophore and privileged structure in medicinal chemistry and exhibits various useful therapeutic activities such as anti-tubercular, antimicrobial, antimalarial, anticonvulsant, anthelmintic, anti-inflammatory, anti-tumor, anti-diabetic, analgesic, neurodegenerative disorders, local brain ischemia, and central muscle relaxant activities. Moreover, it can be easily found in a range of marine or terrestrial natural compounds that have tremendous biological activities. Benzothiazoles have a promising biological profile and are easy to access which makes this pharmacophore an interesting molecule for designing new bioactive benzothiazole...
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Posted by admin on May 31, 2019 in |
Gastroenteritis, especially those caused by bacterial pathogens, remains as one of the major health issues in developing countries. Despite the availability of treatment, people are turning their interest in consuming certain food for its therapeutic value given the adverse effects of medications. This includes the consumption of date fruits (Phoenix dactylifera L.). This study aims to determine the antibacterial effect of two methods of extraction, i.e., hot aqueous extract and methanol extract of Ajwa date fruit against selected gram-negative bacteria causing gastroenteritis. The antimicrobial activities were determined quantitatively using well diffusion assay together with the minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC). Results showed that both hot aqueous and methanol extracts have the potential to suppress the growth of all tested bacteria. The methanol extract had higher inhibitory zones compared to hot aqueous extract, and the zones of inhibition were noted to increase with increase in the extract concentration. S. flexneri was the most sensitive bacteria to both types of extract. The methanol extract was also more...
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Posted by admin on May 31, 2019 in |
1,3-Indanedione derivatives, which are of wide interest because of their diverse biological and chemical applications. A series of novel 1,3-Indanedione derivatives are synthesized via KNOEVENAGEL condensing reaction mechanism by condensing 1,3-Indanedione with the 1-(4-aminophenyl) ethanone to form a styrylated indanedione leading to the formation of different Schiff base (imine) preparation by using different aldehydes with the appropriate solvent mix at a suitable temperature. All the synthetic derivatives were fully characterized by spectral analysis data (FT-IR, NMR, and Mass). The newly synthesized compounds are evaluated for their antimicrobial activity (by using Cup-Plate method against selected bacterial strains amongst S. aureus, E. coli among total compounds, compounds 7 was found to have higher activity against selected strains and the results were found to be as moderate activity, for anti-fungal activity-compounds 2,8 are more potent, compounds are evaluated for their antioxidant NO scavenging (compound 7 is having more activity), for DPPH scavenging (compound 8 is having more activity), and inhibition of lipid peroxidation (compounds 3 and 9 are having more activity), for...
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