Posted by admin on Aug 31, 2018 in |
The present work aims to design, synthesize some novel benzimidazole derivatives and to perform in-vitro evaluation of their antitubercular and antimicrobial activity. In-silico modelling of benzimidazole derivatives was carried out using various softwares such as, ACD Labs Chemsketch, Molinspiration, PASS (Prediction of activity spectra for substances) and Schrodinger Glide XP (Grid based ligand docking with energetics). Nine derivatives (BI 1a, 1b, 1c, BI 2a, 2b, 2c and BI 3a, 3b, 3c) were designed. The designed molecules with required physicochemical properties, drug likeness and obeying Lipinski’s rule of five were selected for the synthesis. The synthesized compounds were subjected to TLC, melting point determination, FTIR and mass spectral studies. All the synthesized compounds showed characteristic peak in FTIR and Mass spectroscopic studies. As per the PASS score and GLIDE score the compounds were selected for biological studies like antitubercular, antibacterial, and antifungal activity. These results are useful for further investigation in the future. All the selected derivatives showed better activity, when compared with standard...
Read More
Posted by admin on Aug 31, 2018 in |
Syzygium cumini (L.) is a widely used medicinal plant for the management of various diseases. Syzygium cumini posses various chemical constituent which are responsible for pharmacological activity. This plant reported to possess many pharmacological activities like anti- diabetic activity, anti-oxidant, anti-inflammatory, anti-diarrhoeal activity, antiviral, antifertility activity, gastroprotective, antipyretic, anti-histaminic, antimicrobial and antiplaque. The present review presents specific information on morphology of plant, cultivation of plant, traditional uses and pharmacological actions of S. cumini (L.). Further applications of Syzygium cumini (Linn.) in the field of novel drug delivery has been also elaborated in the review. Apart from its application in the management of various ailments there is need to explore chemical and toxicity concern of Syzygium cumini...
Read More
Posted by admin on Aug 31, 2018 in |
Excessive antimicrobial use leads to adverse drug effects, thus increased healthcare costs and promoting the emergence of antimicrobial resistance worldwide. The aim of the study was to evaluate the prescription pattern of antibiotics in pediatric outpatients at private hospitals in Rajshahi city of Bangladesh. WHO / INRUD prescribing indicators were used for the analysis of prescription pattern. A total of 329 pediatric prescriptions were analyzed of which 54% male and 46% female. Most of the patients (48%) belongs to the age group of 1 year – 6 years. Body weight was not mentioned in 17% of prescr-iptions, diagnosis was confirmed only in 11% patients and also 11% of children did not take or completed immunization. Among the children born 83% were of caesarian and 17% of normal delivery. The results also indicated that 964 drugs were used by the patients with an average 2.93 per prescription. However, none of the drugs was prescribed in generic name. Interestingly, only 37.24% drugs were prescribed from the national essential drug list. Children...
Read More
Posted by admin on Jul 31, 2018 in |
The rhizome of Tectaria cicutaria has been used in Indian traditional medicine for the treatment of various disorders. Different extracts of the rhizomes of Tectaria cicutaria were subjected to phytochemical analysis, anti-microbial activity and in-vitro anticancer activity. The in-vitro anticancer activity was performed using Sulforhodamine B (SRB) assay against various cancer cell lines namely Human Leukemia Cell Line (K562), Human Nasopharyngeal Cancer Cell Line (KB), Human Colon Cancer Cell Line (HT29) and Human Colon Cancer Cell Line (Colo205). Phytochemical analysis confirmed the presence of bioactive compounds. The total phenolic contents (TPC) and total flavonoid contents (TFC) of ethanolic extract was found significantly higher and showed antimicrobial activity against Proteus vulgaris. Out of the various extracts and cell lines used for studying anticancer activity, the ethanolic extract showed excellent anticancer activity against Human Leukemia Cell Line (K562) with GI50 value 11.9 µg/ml. The present work has for the first time, tried to elucidate the activity of different extracts of Tectaria cicutaria on human cancer cell...
Read More
Posted by admin on Jun 30, 2018 in |
The architecture of cocoons and the chemical compounds present in the cocoons play crucial role to provide protection of the pupae during metamorphosis. Insects spin a silk web as cocoon to facilitate protection and ensuring proper inner environment inside the cocoon during the metamorphosis. Such cocoons are equipped with a variety of chemical compounds which include antibacterial, antifungal, insecticidal and insect repellent etc. Tasar silk worms are wild silkworms grown on forest trees for their commercial value, are subject to harsh environmental conditions in comparison with domesticated Bombyx mori silk worms. In this study antimicrobial compounds were screened from Indian tropical wild tasar cocoons by Fourier transform infrared spectroscopy (FT-IR), Fourier transform-Raman spectroscopy (FT-Raman), Gas chromato-graphy- Mass spectrometry (GC-MS) and identified the chemical compounds by NIST05 MS Library. The wild cocoons possess active alcoholic and phenolic compounds, aromatic organic acids, alkaloids, fatty acids and their derivatives for various protective functions. This chemical defence strategy of wild cocoons was confirmed by evaluating the antimicrobial potential of methanolic extract of Antheraea...
Read More
