Posted by admin on Jul 31, 2017 in |
Objective: To evaluate the prescribing pattern in patients admitted to intensive cardiac care unit, to evaluate direct cost of the treatment in patients admitted in intensive cardiac care unit, to evaluate the rationality of drugs prescribed and to prepare and submit therapeutic guideline for management of ACS. Method: This prospective observational study was carried out in ICCU for a period of ten months. Data were analysed for drug utilisation pattern and direct cost of treatment was calculated using patient’s hospital and pharmacy bills. Rationality of therapy was evaluated based on class of recommendation from Indian guidelines for management of cardiovascular diseases, during the study period 70 prescriptions were screened. Results: The results show that a total of 156 (19.11%) cardiovascular drugs were prescribed to 70 patients admitted in ICCU during the study and anti-anginals 33 (21.15%) were equally used as inotropes 33 (21.15%), followed by anti-platelets 32 (20.51%), anticoagulants 27 (17%), hypolipidemics 21 (14%) and anti-arrhythmics 10(6%). Mean number of drugs per encounter was high (11), which contributed more...
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Posted by admin on Jul 31, 2017 in |
The ancient Chinese formulation Fang Feng Tong Shen San (FFTSS) consists of 17 components. The purpose of this study was to investigate the anti-inflammatory, antioxidant, anti-diabetic, anti-tyrosinase, anti-neuro-degenerative and antimicrobial effects of five commercial preparations of FFTSS and two laboratories constituted mixtures. In-vitro 2, 2-diphenyl-1-picrylhydrazyl (DPPH), lipid peroxidation (LPO), α-glycosidase, tyrosinase, acetylcholinesterase, butyrylcholinesterase, elastase inhibitory and antimicrobial assays were carried out in order to determine the active potential of FFTSS. All commercial preparations have shown antioxidant properties after applying DPPH and LPO assays of an average IC50 of 117.68µg/ml and 2.86µg/ml, respectively. In addition, all commercial preparations exhibited a moderate inhibition against tyrosinase of an average IC50 of 0.353mg/ml while the activity were higher in the formula without salts and excipients reaching an IC50 of 0.077mg/ml. The anti-neurodegenerative property of FFTSS was weak while the inhibitory activity of elastase was stronger. The formula was able to inhibit α-glucosidase in an average of 60.22%. FFTSS showed stronger effect against Staphylococcus aureus but less antimicrobial activity against Gram-negative bacteria. In summary...
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Posted by admin on Jul 31, 2017 in |
Eulophia nuda Lind. belongs to family Orichidaceae and is a rare and endangered orchid. Present research work was carried out on tuber extracts of Eulophia nuda for the evaluation of antimicrobial activities and hepatoprotective. Preliminary phytochemical screening revealed presence of phytochemical constituents like alkaloids, flavonoids, steroids, glycosides (cardiac), tannins, saponins, carbohydrates in three tuber extracts prepared by using solvents (chloroform, acetone and ethanol). Antibacterial activity was carried out with Disc Diffusion method against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. Acetone extract was more effective against Staphylococcus aureus with maximum zone of inhibition 18 mm compared to standard antibiotic Ampicillin with zone of inhibition 20 mm. Antifungal studies was carried out using well diffusion method against Candida albicans, Aspergillus niger and Aspergillus flavus. Chloroform extract was more effective against Aspergillus niger having zone of inhibition 17 mm compared with standard antifungal Fluconazole (20mm). Acetone extract shown the zone of inhibition of 16 mm against Aspergillus flavus compared to standard Fluconazole (22mm). Hepatoprotective activity was carried out as per OECD...
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Posted by admin on Jun 30, 2017 in |
Our previous study highlighted the antimicrobial activity evaluation of Nigella sativa seed oil extract that was obtained from supercritical fluid extraction using carbon dioxide (SCFE-CO2) on Gram positive pathogenic bacteria. The aim of this study was to formulate oil-in-water (o/w) emulsion of previous N. sativa seed oil extract and to investigate its antimicrobial activity against Streptococcus mutans and Streptococcus sanguis as the most common causative bacteria of dental caries. Oil-in-water emulsion containing 10% N. sativa seed oil extract (DLBS1355) exhibited good inhibition activity on both S. mutans and S. sanguis. Time-kill assay and biofilm inhibition assay were conducted using emulsion with 0.5% N. sativa seed oil extract content. The results showed bactericidal and biofilm inhibition activities on both tested bacteria. Antimicrobial activity of the emulsion was found higher on S. sanguis than S. mutans. Results of the present study showed that emulsification process did not significantly affect the antimicrobial activity of N. sativa seed oil extract and the formulated N. sativa oil-in-water emulsion could further be used as an...
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Posted by admin on Jun 30, 2017 in |
The 2-aminobenzothiazole moiety and its derivatives have immense importance in medicinal and pharmaceutical chemistry as a potent biologically active molecules. The synthesis of 2-aminobenzothiazole derivatives carried out from substituted phenyl thiourea which is synthesized by substituted aniline in ionic liquid (1-butyl-3-methylimidazolium) bisulphate ([BMIM] + [HSO4]–), (1-butyl-3-methylimidazolium) tetrafluoroborate ([BMIM] + [BF4]–) and (1-butyl-3-methylimidazolium) hexafluorophosphate ([BMIM] + [PF6]–). Further N-alkylation at amino group of synthesized 2-aminobenzothiazoles was carried out with alcohol using conc. H2SO4 and Schiff bases are also prepared by reaction of substituted 2-aminobenzothiazoles and aromatic aldehydes. ILs are green alternate of volatile organic solvents and they are beneficiary environmentally and economically. The reactivity, reaction rate and yield were enhanced by using ILs and the products were recovered by simple filtration. 2-N-alkylaminobenzothiazoles and Schiff base derivatives are very important structural units in many medicinal compounds. The synthesized compounds can show many biological activities like antitumor, antimicrobial and anti analgesic. The characterization of synthesized compounds was done by elemental and spectral...
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