Posted by admin on Feb 28, 2018 in |
Antibiotics are most important commercially used secondary metabolites, produced by many soil microorganisms i.e., bacteria and fungi and employed in wide range. Most important antibiotics used today are of microbial origin. The emergence of the antibiotic resistance and need of broad spectrum antibiotics is in focus and in demand. In present study, soil samples from different areas were collected i.e., the sampling is classified based on its micro and macro environment (waste polluted soil) (normal street soil) and (agricultural soil), from a local soil and analyzed for the antibiotic production. After primary screening, bacterial isolates were identified as Micrococcus roseus, Brevibacterium sp., Bacillus subtilis, Bacillus anthracis and Bacillus cerus, through biochemical characterization, and fungal isolates were identified as Tricho-cladium opacum, Rhizocotania sp., Epicoccum nipponicum, Aspergillus niger and Cladosporium cladosporides through microscopic and macroscopic identification and checked for antibiotic activity against some common gram positive and negative bacteria namely, Staphylococcus aureus and Escherichia coli. The antibiotic test indicates that Bacillus subtilis, Bacillus anthracis, Epicoccum nipponicum, Aspergillus niger and Cladosporium cladosporides...
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Posted by admin on Jan 31, 2018 in |
A novel Mannich base ligand 1-(2,5-dioxopyrrolidin-1-yl) (4-hydroxy phenyl)methyl)thiourea (PSTU) and its Manganese (II) and Cobalt (II) complexes have been synthesized and characterized by elemental analysis, molar conductance measurements, magnetic susceptibility measurements, FT-IR, 1H NMR and 13C NMR spectroscopic studies. The antimicrobial activities and antioxidant activities of the free ligand and its metal complexes were also performed. The results revealed enhanced antimicrobial activities against Bacillus subtilis (gram+ive) and Escherichia coli (gram–ive bacteria) and also significant antioxidant activity. In addition, DNA binding properties of the ligand and its metal complexes have been investigated by UV-Visible absorption spectroscopy, viscosity measurements, emission spectra and gel electrophoresis, which suggest that the metal complexes act as efficient DNA binders. The results shown that the nuclease activity Co(II) complex was effective which could induce scission of pBr322 super coiled DNA effectively to linear form in presence of H2O2 as oxidizing...
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Posted by admin on Jan 31, 2018 in |
Traditional system of medicine consists of large number of plants with various medicinal and pharmacological importances and hence represents a priceless tank of new bioactive molecules. Coccinia indica belongs to the family Cucurbitaceae. It is a rapidly growing, perennial climber or trailing vine. Traditionally different parts of this plant namely the roots, leaves and fruits are used in folklore medicine for several purposes like jaundice, diabetes, wound healing, ulcers, stomach ache, skin disease, fever, asthma, cough. The leaf and its constituents have been reported to possess anthelmintic activity, antioxidant activity, anti-inflammatory, analgesic and antipyretic activity, antimicrobial activity, antihyper-glycemic activity, hepatoproetcective activity. This review provides adequate information to develop suitable therapeutics out of these plant...
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Posted by admin on Dec 31, 2017 in |
Pyrimidine is a 5-membered heterocyclic ring which is versatile lead compound for designing potent bioactive agents. This interesting group of compound has diverse biological activities such as antimicrobial, CNS depressant, anti-inflammatory, analgesic, anti-convulsant, anticancer, antihelmentic, antioxidant and herbicidal. Available data represents that pyrimidine being heterocyclic planar five membered ring systems has various pharmacological actions and Synthesis of various pyrimidine derivatives and their pharmacological actions discussed below. These derivatives of pyrimidine are analysed in this article for varying pharmacological activities. This review describes various Pyrimidine derivatives have potent biological and pharmacological...
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Posted by admin on Dec 31, 2017 in |
Lantana camara Linn. is considered as a notorious weed and a popular ornamental plant. It is noted from ancient time that plants have been an excellent source of medicine. Since very long time Lantana camara has been reported as one of the most important medicinal plants in the world. Lantana camara is used in traditional medicine system for the treatment of cuts, swellings, ulcers, cataract, bilious fever, itches, eczema, and rheumatism. Various parts of Lantana camara plant are used in the treatment of cold, headache, whooping cough, asthma, chicken pox, bronchitis, eye injuries, and arterial hypertension. L. camara has scientifically studied for various therapeutic activities like antibacterial, antioxidant, antipyretic, insecticidal, antimicrobial, wound healing, etc. Nowadays this plant Lantana camara is worked in several recent advanced techniques like phyto-extraction of heavy metals, phytoremediation of particulate pollution and many others. Various literature has reported the phytoconstituents present in all parts of Lantana camara. In last few decades, scientist and researchers throughout the globe have elaborately examined the chemical composition of the...
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