Posted by admin on Apr 30, 2017 in |
Pterocarpus marsupium Roxb. (Fabaceae) is a moderate to large deciduous tree, belonging to family Fabaceae. It is considered as an extremely useful source of unique natural products for development of medicines against various diseases and for industrial product development. The present study includes physicochemical parameters like ash value, extractive value, fluorescence analysis, moisture content and preliminary phytochemical screening along with mineral analysis. Antimicrobial activity was also assessed for this plant. The physicochemical constants obtained were within normal levels prescribed by standards. The phytochemical studies revealed the presence of primary and secondary metabolites in various solvent extracts of Pterocarpus marsupium bark. The estimated mineral composition was in good amounts which would serve as a device for deciding dosage of ayurvedic drug prepared from the plant. Antimicrobial activity by disc diffusion method indicated the zone of inhibition which ranges from 11-22mm for different extracts. Further evaluation of test samples for minimum inhibitory concentration (MIC) using micro dilution method showed that the methanol extract had exhibited significant activity by inhibiting S.typhi, E.faecalis...
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Posted by admin on Apr 30, 2017 in |
Aristolochia longa L. (Aristolochiacea) is a native plant of Algeria used in traditional medicine. This study was devoted to the determination of polyphenols, flavonoids, and tannins contents of A. longa L. extracts. Extracts were prepared from aerial parts (stems and leaves), fruits and tubers by using various solvents with different polarities such as acetone, methanol and distilled water. Acetone extracts from the aerial parts presented the highest contents of polyphenols (525.43±29.6 µg/mg) followed by fruit aqueous extract (518.54±14.93 µg/mg), while the aerial parts methanol extract shown the highest flavonoid content (52.37±0.94 µg/mg) and exhibited the highest antioxidant capacity of DPPH and reducing power (55.04 ±1.29 µg/mL and 0.2±0.019 mg/mL, respectively), therefore the aerial parts acetone extract showed the highest antioxidant capacity in the β-carotene bleaching inhibition test with 57%. For antimicrobial activity, the fruit methanol extract was too efficient against the bacterial strains tested, whereas no effect was observed when these extracts were tested against fungi. The protein denaturation was found in the aerial parts acetone extract to be...
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Posted by admin on Mar 31, 2017 in |
The present review is, therefore, an effort to give a detailed survey of the literature on its pharamacognosy, phytochemistry, traditional uses and pharmacological studies of the plant Dalbergia sissoo. The genus consists of 300 species among which 25 species occur in India. The generic name Dalbergia honors the Swedish brothers Nils and Carl Dalberg, who lived in the 18th century. Dalbergia sissoo is an important timber species around the world. Besides this, it has been utilized as medicines for thousands of years and now there is a growing demand for plant based medicines, health products, pharmaceuticals and cosmetics. Dalbergia sissoo is a widely growing plant which is used traditionally as anti-inflammatory, antipyretic, analgesic, anti-oxidant, anti-diabetic and antimicrobial agent. Several phytoconstituents have been isolated and identified from different parts of the plant belonging to the category of alkaloids, glycosides, flavanols, tannins, saponins, sterols and terpenoids. A review of plant description, phytochemical constituents present and their pharmacological activities are given in the present...
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Posted by admin on Feb 28, 2017 in |
Despite significant progress made in the treatment of infectious diseases, caused by bacteria and fungi, it remains a major worldwide health problem due to rapid development of resistance against the existing antimicrobial drugs. In the present investigation, a novel series of chalcones 2a–2h were synthesized by the clasein-schmidt condensation of various aldehydes with methyl ketone in the presence of KOH in ethanol which lead to the formation of new chalcones. The structures of these compounds were elucidated by, IR, 1H-NMR spectral data. The in vitro antibacterial activity of these compounds was evaluated against two Gram positive and two Gram-negative bacteria Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Pseudomonas aeruginosa by microdilution method and then the minimum inhibitory concentration (MIC) of these compounds was determined. The results showed that compounds 2d, 2e and 2h showed most promising antibacterial activity as compared to the antibiotics ciprofloxacin in (Tables 1). Compound 2e which carries the nitro substituent appears to exhibit the highest antibacterial activity against all gram positive and gram negative...
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Posted by admin on Feb 28, 2017 in |
Some new hydrazino group substituted benzothiazole derivatives have been synthesized and their characterization was done by IR, NMR and MASS spectral data. The antimicrobial activities of these synthesized compounds was done by cup-plate diffusion method in DMSO against some Gram positive and Gram negative bacteria. Some of synthesized derivatives exhibited potent activity when compared with standard drug...
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