Posted by admin on Jan 31, 2017 in |
1,2,3-Benzotriazole (BTA) is a heterocyclic compound with three nitrogen atoms. The enormous investigations on derivatives of benzotriazole reveals wide applicability of this molecules for tagging and delivering huge number of heterocyclic nuclei. This molecule has been used for the analytical determination of silver as well as a restrainer in photographic emulsions. The effectiveness of 1,2,3-Benzotriazole (BTA) as drug precursors have been drawing attention for a long period. The derivatives of benzotriazole act as agonists for many biologically active proteins. For instance, corozole and alizapride have the inhibitory properties against different proteins and Benzotriazole esters have been reported to work as mechanism-based inactivators for severe acute respiratory syndrome (SARS) 3CL protease. The various derivatives synthesized by different research workers showed antimicrobial activities such as antibacterial, antifungal, antiviral, anthelmintics, antiprotozoal and antimycobacterial activity. The present article throws light on the different derivatives of benzotriazole and their related biological activity, and is reported chronologically. The chronologic development in the synthesis of its derivatives and related changes in therapeutic activity opens new channels...
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Posted by admin on Dec 31, 2016 in |
Background: Antimicrobials are used for bacterial infections & has a great benefits in health related problems of human life. The main objectives of medicinal chemistry is synthesising and producing newer molecules having a valuable significant therapeutic action. Quinolones has a considerable scientific and clinical interest since their discovery. Objective: Quinolones class of drugs are useful in the treatment of serious bacterial infections thus keeping in view a potential approach is made for synthesising & characterizing of newer quinolone derivatives for their biological activity. Method: Quinolone ester was synthesised from Gould-Jacob reaction by using substituted aniline & diethylethoxymethelene malonate (EMME) Results: Solubility of all synthesised compounds were checked in various solvents & were characterized by FT-IR, 1H-NMR. Conclusion: The result of the present study thus demonstrates the anti-microbial activity against gram positive (Bacillus subtilis) & gram negative (Escherichia coli)...
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Posted by admin on Dec 31, 2016 in |
Mimusops elengi L. is an Indian origin herb used in the Unani and other traditional systems of medicine since long time. It is commonly called by the names Spanish cherry, West Indian Medlar or Bullet wood tree. This plant is frequently cultivated throughout India especially in north India for its ornamental appearance and fragrant flowers. All parts of plant such as leaf, root, fruit, seed, bark, flower of Mimusops elengi were reported for treatment of various human ailments in traditional system of medicine. Pharmacological activities like antimicrobial, antifungal, antioxidant and free radical scavenging, anti-inflammatory analgesic, antipyretic, antiurolithiatic, cytotoxic, diuretic, neuroprotective, anti-amnesic, cognitive enhancing, antihyperglycemic, antihyperlipidemic, hypotensive, antiulcer, anthelmintic, antitumor, wound healing, larvicidal activities have been scientifically evaluated for various parts of this plant. A number of phytochemical constituents have been identified in this plant that may be responsible for its pharmacological activities. So many articles are available on Mimusops elengi L., but from Unani literature the discussion is very limited. This review is an effort to summarize the detailed...
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Posted by admin on Dec 31, 2016 in |
Five novel benzimidazolium salts were synthesized as N-heterocyclic carbene (NHC) precursors (1a–e). They were characterized by different techniques. The antimicrobial activities of these compounds were tested. The compounds showed moderate activity against three Gram (+) and seven Gram (-) bacteria in comparison to tetracycline, which was used as the standard antibiotic, whereas all the compounds (1a-e) showed no activity against the test yeast C....
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Posted by admin on Dec 31, 2016 in |
Ethonolic whole plant extract of Musa paradisica has a multiple pharmacological activities including antimicrobial, antiviral, anti-inflammatory, anticancer effects. The present study aims to determine the effect of Musa paradisica on serum and tissue superoxide dismutase (SOD) levels and the histology in carbon tetrachloride (CCl4)-induced liver injury. Wister rats aged were injected Intraperitoneally with 50% CCl4 in olive oil. Musa paradisica was orally administered before or after CCl4 treatment in various groups. Twenty-four hours after CCl4 injection, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, serum and liver superoxide dismutase (SOD) activities were measured and Histological changes of liver were examined by microscopy. Serum ALT and AST activities significantly decreased in a dose-dependent manner in both pre-treatment and post-treatment groups with ethonolic whole plant extract of Musa paradisica. The present study demonstrates that Musa paradisica possesses hepatoprotective effects against CCl4– induced hepatotoxicity and that the effects are both preventive and curative. Musa paradisica should have potential for developing a new drug to treat liver...
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