Posted by admin on Mar 31, 2016 in |
The present work aims to examine the antimicrobial activity of three medicinal plant extracts grown in Saudi Arabia namely Pulicaria crispa, Achillea fragrantissima and Cleome Africana against 10 clinical isolates of multi-drug resistant bacteria (MDR) that belong to four species, Staphylococcus aureus, Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumonia. The antibacterial potential of the methanolic plant extracts was assessed by the agar well diffusion method and expressed in terms of diameters of inhibition zone. The outcomes of these experiments indicated that each extract has shown an activity against four resistant isolates at least, with maximum zone of inhibition 19 mm recorded by P. crispa extract against S.aureusstrain (1). As a new finding, it was observed that C. Africana extract has bioactivity as antibacterial agent against maximum number of resistant isolates (seven out of ten tested strains) including all tested isolates of S.aureus (ranged between 7 and 14 mm). Methanolic extract of A. fragrantissima demonstrated two considerable growth inhibition against one isolate of both S.aureus and Ps. aeruginosa. The chemical...
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Posted by admin on Mar 1, 2016 in |
Several 3, 6-substituted – [1,2,4] Triazolo [3,4-b][1,3,4] Thiadiazole}-2H-Chromen-2-ones(5a-5j) have been synthesized from ethyl-2-oxo-2H-chromene-3-carboxylate (1) through a multistep reaction sequence. Compound 1 reacted with hydrazine hydrate in the presence of ethanol to give 2-oxo-2H-chromene-3-carbohydrazide (2) which on treatment with carbon disulphide and methanolic potassium hydroxide yielded corresponding potassium dithiocarbazates (3). They were then converted in to 3-(4-amino-5-sulfonyl-4H-1, 2, 4-triazol-3-yl)-2H-chromene-2-one (4) by refluxed with aqueous hydrazine hydrate. The title compounds 5a-5j was prepared by condensing 4 with various substituted aromatic acids in the presence of phosphorus oxy chloride. The synthesized compounds have been characterized by the physical (melting point and TLC) and spectral (IR, 1NMR, 13C NMR and MASS) data. All the compounds were screened for their antimicrobial and anti-tubercular activities. The antimicrobial activity was examined against four types of bacteria by cup plate method. Compounds 5b, 5c, 5g, 5e & 5a showed maximum activity at both 50 and 100µg/ml concentrations. Compounds 5a, 5b, 5c, 5d, 5e, 5g, 5h & 5i showed significant activity against ATCC 27294 H37 RV strain and...
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Posted by admin on Mar 1, 2016 in |
Semecarpus anacardium plant derivatives has been used since antiquity, The fruit and nut extract of Semecarpus anacardium shows various activities like antiatherogenic, anti-inflammatory, antioxidant, antimicrobial, antireproductive, CNS stimulant, hypoglycemic, anticarcinogenic, antifertlity effects. The present study is an attempt to explore the antiovulatory effect of aqueous and ethanolic extracts of fruits of Semecarpus anacardium plant in female albino rats. Objective: To study the antiovulatory activity of aqueous and ethanolic extracts of Semecarpus Anacardium fruit in female albino rats. Materials and Methods: Total of 54 Wistar female albino rats were selected weighing about 150 – 200 grams with atleast three regular estrous cycles were divided into 9 groups containing 6 ratseach were administered aqueous and ethanolic extracts of Semecarpus anacardium fruit both were administered in doses of 200,400,600,800 mg/kg, b.wt for different group daily for 21 days and estrous cycle monitored for 30 days daily. Control group received vehicle (Tween 80 1%, p.o. daily) and the estrous cycle was monitored daily, doses for the study selected after acute toxicity studies. Results:...
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Posted by admin on Mar 1, 2016 in |
Norfloxacin is slightly soluble in water and is a synthetic antimicrobial fluoroquinolone. Absorption of Norfloxacin is slightly impaired when it is administered with food as evidenced by a reduction of approximately 30% in the peak serum concentration. In the present study concept of mucoadhesive suspension is introduced to overcome the limitation of drug that has poor oral bioavailability and to increase the residence time of drug by bringing the drug in the vicinity of absorption window by formulating it in mucoadhesive drug delivery system. An attempt has been made to increase the bioavailability of Norfloxacin by formulating mucoadhesive suspension in different Polymers. Increase in time, speed of homogenization decreases the particle size and increases the zeta potential. Batches formulated with soyalecithin, antinucleating agents, showed decreased particle size. The comparative studies of dissolution studies showed, 99.55% of processed suspension released in 10Min. as compared to 101.63% released in 40Min. for marketed suspension respectively. The reason for increased percent release of drug in short time (10Min.), for processed suspension is, more...
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Posted by admin on Mar 1, 2016 in |
The plant Hugonia mystax L., is a woody evergreen liana belonging to the family Linaceae, locally knows as Modirakanni. Ethnobotanically the tender fruits were used for rheumatism and biological activities like antimicrobial were reported. Present study find outs the scientifically evidence of fruits of Hugonia mystax for its antioxidant property. The different extract of fruits was obtained by successive extraction with petroleum ether, chloroform and ethanol by soxlet method. These extracts were taken for an in- vitro antioxidant study, was carried out by using various in vitro antioxidant screening models like DPPH radical scavenging activity, total phenolic content was determined. The successive plant extract showed good dose dependent activity by inhibiting DPPH and total phenolic content. Antioxidant activity of fruits showed a greater free radical sequestering activity. In the present study, ethanol extract showed a greater antioxidant activity was found to be 1000 µg/mL expressed as significant antioxidant activity of Hugonia mystax. This might be due to the presence of phytocompounds flavonoids, phenols, saponins, steroids, tannins and terpenoids present...
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