Posted by admin on Jun 30, 2021 in |
Succinimide and its derivatives are important substitutes of many medicinal compounds in the pharmaceutical field. One of the essential objectives in heterocyclic and medicinal chemistry is the synthesis of molecules having importance as therapeutic agents. Heterocyclic compounds and their derivatives contain an imide ring that can easily cross biological membranes in-vivo. Mannich reactions are one of the fundamental methods of C-C bond forming reactions in organic synthesis and withstand a diversity of functional groups. In view of this, the Mannich base1-((2,5-dioxopyrrolidin-1-yl)phenyl)methyl)thiourea and a few of its transition metal complexes with Mn(II) and Co(II) have been synthesized. The newly synthesized ligand and its metal complexes have been characterized by elemental analysis, molar conductance and FT-IR, UV-Visible NMR, Mass spectral studies, and magnetic measure-ments. The ligand and the corresponding metal complexes were screened for their antibacterial and antifungal activities. The metal complexes have shown marked activity against selected microorganisms than the...
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Posted by admin on Jun 30, 2021 in |
Phytotherapeutical properties of blackthorn (Prunus spinosa L.) are well known and used in Bosnia and Herzegovina traditional medicine. This study aimed to investigate total phenolic content, total anthocyanin content, total flavonoid content, antioxidant and antibacterial activities of different ethanolic extracts from wild blackthorn flowers, leaves and fruits, obtained by microwave-assisted extraction and ultrasound-assisted maceration. The mineral profile has been identified using flame atomic absorption spectrophotometry. Plant samples were collected from three areas in Bosnia and Herzegovina. In order to detect antioxidant activity of extracts, DPPH assay was carried out. DPPH radical scavenging activity was higher for flower and fruit extract than leaf extracts, regardless of the extraction method used. Ethanolic extracts show significant antimicrobial activity against all analyzed bacterial strains (Staphylococcus aureus, Bacillus subtilis, Enterococcus faecalis, Salmonella enterica, Escherichia coli, Pseudomonas aeruginosa and antifungal activity against Candida albicans). Blackthorn fruits contained high mass fractions of some essential minerals on dry mass basis, including K, Ca, Mg, Na, Fe, and Cu. Blackthorn flower, leaf and fruit extracts exhibit a high...
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Posted by admin on May 31, 2021 in |
Benzoxazole and its analogues play an important role as therapeutic agents and exhibit good cytotoxic as well as antimicrobial activity. In the present study, benzoxazole analogues have been prepared by synthetic route; their spectroscopic evaluation was carried out, and then the synthesized compounds were screened for their cytotoxic activity by Allium cepa root model as well as antimicrobial activity by cup plate method. The synthesis and cytotoxic activity of a novel series of Schiff’s base was carried out by reacting the amino group of the 4-Benzoxazol-2-yl-phenylamine with different aromatic/ heteroaromatic aldehydes in the presence of polyphosphoric acid to give 4-(1,3-Benzoxazol-2-yl)phenyl]-1-(Substituted phenyl) methanimine (4a-4h) also Diazotization reaction of (4-Benzoxazol-2-yl phenyl) with β napthol gave 2-((4-(benzo [d]oxazole-2-yl)phenyl) diazenyl) naphthalene-2-ol (4i). The cytotoxic and antimicrobial activities of the synthesized compounds were determined by using the onion root model and cup plate method, respectively. The activity data of compounds was compared with standard drugs Cefixime for antibacterial activity and miconazole for antifungal was used as a standard, and cyclophosphamide was used as a...
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Posted by admin on May 31, 2021 in |
In the present study, 3-naphthoyl propionic acid and various appropriate reagents were used to synthesize, ten new synthetic furanone derivatives, i.e. 3-arylidene-5-(naphthalen-2-yl) furan-2(3H)-one (2-11). Selected furanones were made to react with ammonia and benzylamine to yield analogous pyrrolones (12-16) and N-benzyl pyrrolones (17-21), respectively, which were characterized on the basis of 1H NMR, Mass spectroscopic data. Synthesized compounds were tested for anti-inflammatory activity by the carrageenan-induced rat paw edema method, compounds displaying compelling anti-inflammatory activity were screened for analgesic activity by employing the acetic-acid induced writhing method, and selected compounds were tested for ulcerogenic activity. Screening of the newly synthesized compounds was also done for their antibacterial profile against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and antifungal activity against Aspergillus flavus, Aspergillus niger. One of the derivatives numbered (9) displayed strong anti-inflammatory, analgesic, and antimicrobial activities, and it could prove as a promising candidate for the development of new and safer...
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Posted by admin on Apr 30, 2021 in |
Sulfonamides, sometimes called sulfa drugs, are the first drug that is largely employed and systematically essential for preventive and chemotherapeutic agents against various bacteria. Sulfonamides possess a wide range of pharmacological activities such as Oral hypoglycemic, antileprotic, anti-epileptic, anti-hypertensive, anti-bacterial, anti-protozoal, anti-fungal, antiretroviral, non-peptidic vasopressin receptor antagonists, anti-cancer, anti-inflammatory, translation initiation inhibitors, and used as a diuretic. The rapid evolution of drug-resistant bacterial and fungal infections has demanded a universal effort to search for new generation sulfonamide derivatives. The sulphonamides or sulfa drugs competitively inhibit folic acid synthesis in microorganisms and subsequently inhibit the multiplication of bacteria but do not actively kill them. These sulfonamides have a variety of synthetic reactions to work with. On the basis of the literature survey, the present review highlights research work in the recent decade, including potential antimicrobial activities of sulfonamides compounds. This review covers current advances related to synthesis and pharmacological effects of sulfonamides, especially in apprehension to anti-microbial...
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