Posted by admin on Feb 25, 2015 in |
The investigation of terrestrial plants origin aimed at searching new natural biologically active compounds is a central issue of this kind of studies, through structure elucidation combined with biological tests. We investigated the biologically active secondary metabolites from Leucas lavandulaefolia towards various effects on the behavior of Aphanomyces cochlioides zoospores and with antimicrobial activity. We purified the following compounds acacetin, chrysoeriol, luteolin, acacetin 7-O-β-D-glucuronide, acetoside, isoacetoside, salicylic acid and caffeic acid. Their structures were elucidated by spectroscopic analyses and compared with those of the reported data. Five compounds (luteolin, acacetin 7-O-β-D-glucuronide, acetoside, isoacetoside, and salicylic acid) were isolated from L. lavandulaefolia for the first time ever. It was found that luteolin showed a strong attractant and encystment activity toward zoospores of the phytopathogenic fungus A. cochlioides zoospores. Chrysoeriol also showed an attractant activity towards A. cochlioides zoospores. This is the first research report of L. lavandulaefolia regarding zoospores bioassay. Antibacterial assay on these compounds indicated that they have antimicrobial activity against the tested bacteria Bacillus subtilis and Staphylococcus aureus....
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Posted by admin on Feb 25, 2015 in |
Habenaria plantaginea Lindl. (Orchidaceae) is used as a medicinal plant in several countries. In this study, ethanol, chloroform and water extracts of Habenaria plantaginea were evaluated for antibacterial activity against bacterial (MTCC) strains. Antibacterial activity of this plants extracts were performed using agar disc diffusion method. The antibacterial activity of ethanol extracts showed more effective followed by water and chloroform extracts against all the bacterial strains. Preliminary phytochemical studies were performed for the presence and absence of secondary metabolites in the whole plant. The Minimum Inhibitory concentration (MIC) exhibited by H. plantaginea extract against the bacterial strains ranged between 0.125 mg/ml to 6 mg/ml. The presence of bioactive constituents is associated with the antimicrobial activity of various solvent extracts of this plant was carried in attempt to support the use by medicinal practitioner for the treatment of various diseases. Medicinal importance of this orchid will target to meet the therapeutic...
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Posted by admin on Jan 30, 2015 in |
Nystatin, an antifungal drug for mucosal infections has a large dosing frequency and is rapidly inactivated by acids. In order to increase drug stability and reduce dosing frequency and reduce dosing frequency and gastric irritation, formulation into inert lipid matrices as solid lipid microparticles may be utilized. The formulations were done from Shea butter extract using either Tween 20 or Tween 65. The mixture was homogenized in each case to enable the incorporation of drug into solid lipid microparticles. The properties of the microparticles were evaluated by determination of size, percentage recovery, encapsulation efficiency and drug release in simulated gastric fluid (without enzymes). The antimicrobial activities of the microparticles were then investigated by the agar-diffusion inhibition zone diameter method against Candida albicans, using pure nystatin dispersed in DMSO as a control. Micron-sized particles with a narrow size distribution were obtained. Though drug encapsulation efficiency and loading were very low, good activity was exhibited against the test organism, in vitro. The antimicrobial activity and release profile obtained with Batch A...
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Posted by admin on Dec 25, 2014 in |
In this study the neuroprotective activity extract hydroalcoholic of AO against behavioral and biochemical parameters induced by subcutaneous injection of rotenone was evaluated, important for the understanding of Parkinson´s disease, which is the most common neurodegenerative disorder affecting movement. Rotenone is a potent hydrophobic pesticide and a highly selective inhibitor of complex I in the electron transport chain. Anacardium occidentale (AO), popularly known as cashew, is a tropical tree native to north and northeast Brazil. Peduncles (pseudofruit) and nuts can be eaten raw or converted into various nutritional products (juice, tea, jam, and beverages). AO has been studied for its anti-inflammatory, antimicrobial, antitumor, molluscicides and antidiabetogenic activity. Behavior evaluations were performed using the models of open-field, rotarod, on horizontal bar and elevated T-maze. The in vivo antioxidant activity was evaluated in the substantia nigra (SN), cortex and striatal region by lipid peroxidation after behavioral tests. Systemic administration of rotenone produced hypolocomotion, muscle incoordination and memory deficit. AO administration (150 and 600 mg/kg, p.o.) improved rotenona induced dysfunctional behavior (locomotor,...
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Posted by admin on Dec 25, 2014 in |
Research in medicinal plants has gained a renewed focus recently. The prime reason is that other system of medicine although effective come with a number of side effects that often lead to serious complications. Plant based system of medicine being natural does not pose any serious problems. Although Emblica officinalis has a range of medicinal applications, but it is the need much period of time to explore. The use of Emblica officinalis as antioxidant, immune modulatory, antipyretic, analgesic, cytoprotective, anti ulser, immune modulatory, anti inflammatory, antitussive and gastroprotective are also studied. Emblica officinalis having a strong Memory enhancing property, in lowering cholesterol level, applicable in ophthalmic disorder, are reviewed. The effects of Emblica officinalis also take account as an antimicrobial action and in neutralizing snake venom are also...
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