Posted by admin on Oct 1, 2014 in |
Nasal infection or sinusitis is an inflammation of nasal passages caused by both viral and bacteriological pathogens. Antimicrobial resistance has universally recognized as growing problem concern about suitable therapy for nasal infection. The study was aimed at determining the prevalence and antimicrobial susceptibility against nasal infecting microorganisms. 50 clinical samples were taken from OPD of GMC Hospital, Bhopal (MP), India. Of the samples analyzed, 47 bacterial strains were isolated out of which 29 strains were of Gram positive bacteria (8 strains were of Staphylococcus aureus, 6 of Staphylococcus epidermidis, 7 of Streptococcus pneumoniae and 8 of Corynebacterium diptheriae) and 18 strains were of Gram negative bacteria (8 of Escherichia coli, 6 of Pseudomonas aeruginosa and 4 of Neisseria meningitidis). Antimicrobial susceptibility assay was performed by disc diffusion method according to the reference criteria of clinical and laboratory standard institute guidelines. In the present study antibiotic susceptibility pattern results showed maximum level of resistance in gram positive strains S. aureus 8 (100%), S. epidermidis 6 (100%) and C. diptheriae (8...
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Posted by admin on Oct 1, 2014 in |
Cosmetic applications of spices and herbs are well recognized. Apart from preservative and antimicrobial activities, spices display copious antioxidant activity. Inclusion of these antioxidants in topical supplements has proved to be effective against oxidative aging. However, food and contact allergy to most spices make it mandatory to screen for skin and eye irritation activities before cosmetic applications. In this report, we have aimed to compare ethanolic extracts of five seeds belonging to family Apiaceae (C. carvi, C. cyminum, C. sativum, T. ammi, A. graveolens) concerning their antioxidant activities, phenol and flavonoid content, in-vitro cytotoxicity, and eye irritation tests. Our investigation illustrates that C. carvi expresses the highest antioxidant activity among these. Further, the polyphenol content and antioxidant activity are positively correlated in all samples. In-vitro cytotoxic analysis on chick embryo fibroblasts and in-vitro eye irritation assays demonstrate 200µg/ml concentration of these extracts can be safely used for cosmetic...
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Posted by admin on Oct 1, 2014 in |
Novel Schiff base comprising 4-aminoantipyrine with Biginelli adducts of salicylaldehyde has been designed and synthesized. Solid metal complexes of this Schiff base with Ni(II), Zn(II), Cd(II) and Hg(II) metal ions were synthesized and characterized by elemental analysis, magnetic susceptibility, molar conductance, ESI mass, IR, NMR, and UV-Vis spectral studies. From the data, it has been observed that the complexes had the composition of ML2 type, diamagnetic nature and a tetrahedral geometry around the metal ion except for Ni(II) complex which has square planar geometry. The Ligand and its complexes have been screened for their in-vitro antifungal and in-vitro antibacterial activities against the fungi i.e., Candida albicans, Aspergillus flavus, Penicillium spp., Aspergillus niger and Trichophyton and the gram-negative bacteria Escherichia coli, Vibrio spp., Pseudomonas aeroginosa, Vibrio para haemolytic, Salmonella spp., Aeromonas spp., Klebsiella spp., Proteus spp. and gram-positive bacteria Bacillus spp and Staphylococcus aureus. The in-vitro antimicrobial activities of these metal complexes found to be stronger than the...
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Posted by admin on Oct 1, 2014 in |
Impatiens balsamina belonging to family Balsaminaceae is commonly known as terda. The plant has an extensive range of phyto-constituents like naphthoquinones, coumarins, glycosides, phenolic acids, flavonoids, anthocyanidins and steroids which have effective antimicrobial, anti-anaphylaxis, anti-allergic, antipruritic, and anti-inflammatory activity. Potent naphthoquinones like lawsone, methylene-3, 3’-bilawsone and lawsone methyl ether are present in the leaves of the plant that exhibits was proved to possess an intensive antitumor activity. Taking into account these ethnobotanical, nutritional, medicinal and commercial values of I. balsamina, a simple, rapid and sensitive High-Performance Liquid Chromatography method for quantification of three naphthoquinones in is developed. Jasco CrestPak C8 (4.6×250mm, 5μm) RP-HPLC column was used as the stationary phase. Sodium acetate (pH3.2): ACN (50:50% v/v) was used as mobile phase with flow rate 1ml/min and detection at a wavelength of 280nm using PDA multi-wavelength Detector. The developed method was validated for linearity, accuracy, precision, and system suitability. LOD for naphthoquinones was found to be 200ng/mL, whereas LOQ for the same was found to be 600ng/mL. The method was...
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Posted by admin on Sep 1, 2014 in |
Flavones are an important class of flavonoids having a wide range of biological activities like antioxidant, anti-inflammatory, anti-oestrogenic, antimicrobial, anti-allergic, antioxidant, vascular, antitumor, and cytotoxic activities. First cyclin-dependent kinase inhibitor, flavopiridol, which is a flavone is approved as an orphan drug in Europe for the treatment of relapsed chronic lymphocytic leukemia. So, these structural motifs may show potential activity to wide therapeutic conditions. Thereby synthesis of flavone is an important aspect in medicinal chemistry. This article covers the synthetic strategies available in the literature and their usefulness in terms of yield and reaction condition and the biological activity exerted by the natural and synthetic flavone derivatives and their probable mechanism of action. It is expected that this review may be helpful for medicinal chemist in research regarding flavones with new therapeutic...
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