Posted by admin on Jun 1, 2014 in |
In the present endeavour, bioprospecting potentials (antimicrobial activity, antibiotic susceptibility pattern, enzyme activity and dye degradation ability) of endophytic bacteria isolated from different plants were explored. Total of thirty bacterial endophytes were isolated from the leaves of selected plants by using sterilization treatment followed by serial dilution agar plate technique. All the isolates were evaluated for the antimicrobial activity against 7 pathogenic strains including 2 Gram positive bacteria (Staphylococcus epidermidis and Bacillus amyloliquifaciens)and 2 Gram-negative bacteria (Escherichia coli and Salmonella enterica ser. typhi)and 3 fungi (Aspergillus fumigatus, Aspergillus sp. and Candida albicans) using agar well diffusion method. Of the 30 bacterial isolates, twenty endophytic bacterial isolates exhibited both antifungal and antibacterial activity. It was observed that 33.33% of isolates exhibited urease activity, 66.66% amylase activity, while 50% esterase activity. Malachite green degradation was observed in 16 (53.33%) endophytic bacterial isolates. The antibiotic susceptibility pattern of endophytic bacterial isolates was evaluated. Five Gram negative bacterial isolates were sensitive to Amikacin, Levofloxacin, Cephotaxime, four isolates sensitive to Aztreonam and three isolates...
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Posted by admin on Jun 1, 2014 in |
Acne vulgaris is a most common skin disorder of pilosebaceous unit that affect areas containing the largest oil glands, including the face, back, and trunk. It is generally characterized by formation of seborrhea, comedone, inflammatory lesions. Propionibacterium acnes and Staphylococcus epidermidis have been recognized as pus-forming bacteria triggering an inflammation in acne. Staphylococcus aureus support to cause inflammation in acne. The present research work deals with formulation and evaluation of herbal gels against this etiologic agent of acne vulgaris. The ethanolic extract of Neem (leaves), Nutmeg (fruit), and Black pepper (fruit) were prepared and formulated into a topical gel. In vitro antibacterial activity was performed against P. acnes, S. epidermidis and S. aureus, using agar well diffusion method. The measured zones of inhibitions of the prepared formulations were compared with standard antibiotic (Clindamycin) and standard marketed topical herbal formulation. The prepared gels were evaluated for pH, viscosity, spreadability, stability, drug content, acute skin irritancy activity and in vitro diffusion. The results from the agar well diffusion showed that Neem,...
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Posted by admin on Jun 1, 2014 in |
Cassia fistula Linn. (Family: Caesalpinaceae), commonly known ‘Sonali’ or ‘Bandarlati’, has been used in different traditional system of medicines for various ailments since ancient times. Cassia fistula grows throughout in Bangladesh and in many other Asian countries such as India, China, Hong Kong, Philippines, Malaysia, Indonesia, and Thailand. This article aims to provide a comprehensive review on the phytochemical and pharmacological aspects of Cassia fistula. In traditional medicine, it has been used in the treatment of diabetes, hematemesis, leucoderma, pruritis, intestinal disorder and as antipyretics, analgesic and laxative. The fruits, stem bark, and leaves of this plant contain a variety of biologically active compounds such as anthraquinones, flavonoids, flavon-3-ol derivatives, alkaloid, glycosides, tannin, saponin, terpenoids, reducing sugar and steroids those have various medicinal properties. The fruit and stem bark extract shows various activities like antipyretic, anti-inflammatory, antioxidant, antidiabetic, hypolipidemic, hepato-protective, antimicrobial, antitumor, antiulcer etc. The article reviews the various activities of the...
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Posted by admin on May 1, 2014 in |
This overview firstly highlights biology of endophytic microbes from medicinal plants as well as their chemistry with emphasis on the important merging of microbiology and natural products chemistry and its role in improving our current knowledge of endophytic associations in medicinal plants. Secondary metabolites of medicinal plants-derived endophytes reported in recent years are grouped according to their bioactive properties including antitumor, antimicrobial, growth-promoting, antioxidant, antithrombotic, insecticide and other functions. New insights on distributing characteristics and biodiversity of these endophytes including bacteria, actinomycetes and fungi are also presented. It suggested that endophytic microbe from medicinal plant is a treasure trove of bioactive natural products with a good and potential application prospect in pharmacy and...
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Posted by admin on May 1, 2014 in |
In this present study, we investigated the phytochemical constituents screening and in-vitro antioxidant activity of hydro-alcoholic (methanol 70%v/v) extracts of Soymida febrifuga bark. Soymida febrifuga is a huge tree bearing deciduous foliage and having a tough bark belonging to the family Meliaceae. Traditionally the different parts of plant such as root, leaves, bark, and flower are used for various human ailments. Thebark extracts are used in treatment of rheumatoid arthritis asthma and good for ulcers .The decoction of the bark has bitter resin used in vaginal infections, rheumatic pains , stomach pains, wounds, dental diseases, uterine bleeding and haemorrhage .The bark is also used as an acrid, refrigerant, laxative, good for sore throat, removes ‘vata’ and cures ‘tridosha’ in Ayurveda. Apart from many uses various active constituents like methyl angolensate, luteolin 7-O-glucoside, quercetin, sitosterol, myrecetin were isolated. It also possesses various pharmacological activities such as anticancer, antihelmenthic, antioxidant ant malarial and antimicrobial. In view of this the hydro alcoholic bark extract of S. febrifuga produced a dose dependent inhibition...
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