Posted by admin on May 1, 2014 in |
Bacteriocins are proteinaceous substance produced by bacteria to inhibit the growth of similar or closely related bacterial strains. They are typically considered to be narrow spectrum antibiotics produced by both gram negative and gram positive range of bacteria which possess antimicrobial properties and inhibitory towards sensitive strains. Bacterocins are safer than antibiotic. They can be used from natural material (probiotics). Bacteriocins of lactic acid bacteria are considered as safe natural preservatives or bio preservatives. A total of nineteen colonies were picked from the various samples i.e. Curd, Condensed milk, Soil and Raw milk. All were subjected to bacteriocin assay and a total of six (6) strains showing relative positive results were selected and subjected for further characterization. Among all six (6) isolates (P1, R3, R6, R7, R8, T7), P1and R7 strains showed promising results against various test organisms with the observed bacteriocin activity. During preservative studies, addition of cell free bacteriocin extract of P1 strain showed positive result for preservation of raw milk up to 4days without any change...
Read More
Posted by admin on May 1, 2014 in |
Some transitional metal ions complexes with 3-{[(Z)-(4-hydroxyphenyl) methylidene] amino} benzoic acid with general formula [M(L2)xH2O], [where M = Mn(II),Co(II), Ni(II),Cu(II), Zn(II), Pd(II) and Pt(II)metal ions and L=3-{[(E)-(4-fluorophenyl) methylidene] amino} benzoic acid ] have been synthesized and characterized on the basis of elemental analysis, conductance, magnetic susceptibility, IR, UV-Visible, ESR, X-RD and TGA/DTA. The complexes are covalent in nature with octahedral geometry. The covalency factor (β), bonding parameter were calculated. The dentistry of the complexes was in the range between 1.5 to 1.90 m/dm3 in toluene and the spectral line indicates low crystallinityof the complexes. All the complexes are non-electrolytic in nature. All the complexes are paramagnetic in nature expect Zn(II) complexes indicates slight participation of the 3d electron in bond formation. The ligand and its complexes have been screened for their antimicrobial activity with some bacteria it shows that antibacterial and antifungal activity complexes are more active towards these bacteria than Schiff...
Read More
Posted by admin on May 1, 2014 in |
In this present study, we investigated phytochemical constituents screening and In-vitro antioxidant activity of hydro-alcoholic (methanol 70%v/v) extracts of Soymida febrifuga bark. Soymida febrifuga is a huge tree bearing deciduous foliage and having a tough bark belonging to the family Meliaceae. Traditionally the different parts of plant such as root, leaves, bark, and flower are used for various human ailments. Thebark extracts are used in treatment of rheumatoid arthritis asthma and good for ulcers .The decoction of the bark has bitter resin used in vaginal infections, rheumatic pains , stomach pains, wounds, dental diseases, uterine bleeding and haemorrhage .The bark is also used as an acrid, refrigerant, laxative, good for sore throat, removes ‘vata’ and cures ‘tridosha’ in Ayurveda. Apart from many uses various active constituents like methyl angolensate, luteolin 7-O-glucoside, quercetin, sitosterol, myrecetin were isolated. It also possesses various pharmacological activities such as anticancer, antihelmenthic, antioxidant ant malarial and antimicrobial. In view of this the hydro alcoholic bark extract of S. febrifuga produced a dose dependent inhibition of...
Read More
Posted by admin on May 1, 2014 in |
A new series of thiazolo [3′,2′;1,2] pyrimido [5,4,e] pyrimidines and thiazolo [3′,2′;1,2] [1,2,4] triazolo [3”,4”-c]pyrimido [5,4-e] pyrimidines linked to 2-pyrazolin-5-one moiety were prepared by derivatization of the hydrazine functionality of the heterocyclic hydrazine with various reagents. The newly synthesized compounds were characterized by elemental analyses and spectroscopic techniques. The antimicrobial, anti-inflammatory, and analgesic activities of the synthesized compounds were evaluated using agar diffusion method, carrageenan-induced paw edema, and writhing assays, respectively. The finding of the study showed that, compounds 1a, b, 3a, b, 7b and 15a, b have excellent antimicrobial potency. In the anti-inflammatory activity, compounds 2a and 2b showed remarkable activities (30% and 32%, respectively). For the analgesic activity, the same compounds 2a and 2b gave significant activities (27% and 29%,...
Read More
Posted by admin on May 1, 2014 in |
Probiotics are defined as “Live microorganisms” which when administered in sufficient amounts confer a health benefit to the host. They are consumed as microbial food supplements.The mechanism of action of probiotics is associated with their ability to enhance immune response, compete with pathogenic microbes for adhesion sites, to antagonize these pathogens and production of antimicrobial substances. Immunomodulatory effect of probiotics can be explained by molecular and proteomic studies. Health benefits of probiotics includes prevention and treatment of various health conditions and diseases such as gastrointestinal disorders, lactose intolerance, irritable bowel syndrome, inflammatory bowel disease, Necrotising colitis, allergies, urogenital infections, various cancers, Arthritis, AIDS, Upper respiratory infections, oral health such as prevention of dental caries, periodontal diseases and haliotis as well as many other effects which are under exploration. The result of several clinical investigations proposes that probiotics may exert beneficial effect in preventing and treating various diseases to manage human health. Though, many of this clinical research needed validation to provide results for clinical regime. This review illustrates the...
Read More
