Posted by admin on Sep 1, 2013 in |
Allium sativum linn (Garlic) belong to family Liliaceae has been widely known since ancient times for medicinal use and for flavouring food. It contains large amount of sulphur containing compounds like Alliin, Allicin, Ajoene, Diallyl sulphide, Diallyl disulphide Diallyl trisulfide, Vinyldithiines which has beneficial activity including Antithrombotic, Anticancer, Antiviral, Antifungal and Antimicrobial, Anti-inflammatory etc. Ajoene is known as an inhibitor of platelet aggregation induced by all known agonists which also a good inhibitor of tumour and antifungal property. The present study deals with pharmacognostical parameters for bulb of Allium sativum which mainly consist of the detailed macromorphology of cloves and bulb, microscopy and micrometry of transverse section of cloves of Allium sativum linn which has been carried out by using MOTIC Digital Microscope. The other parameters like physicochemical constant and phytochemical screening were studied. The study will provide referential information for the correct identification and standardization of crude...
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Posted by admin on Sep 1, 2013 in |
The present study was an attempt to investigate the feasibility of the matrix based sustained release unit dosage formulation of cefixime trihydrate. Matrix tablets were prepared by using xanthan gum along with the other polymer combinations (Guar gum, sodium alginate and hydroxypropylmethyl cellulose). Effect of different formulation variables like polymer concentration, ratio of polymer combination and compression force was evaluated. The Fourier transform infrared spectroscopy,differential scanning calorimeter and X ray diffraction analysis were also carried out to evaluate physico-chemical compatibility between drug and excipients. In vitro release results suggested a 24 h controlled drug release from the prepared tablet of cefixime trihydrate. Swelling and erosion studies were performed to verify the release mechanisms involved in the formulation. In vitro antimicrobial study was also performed to check the synergistic efficacy of CFT with excipients. The formulations were found to be stable up to 3 months of stability testing at 40ºC/75%...
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Posted by admin on Aug 1, 2013 in |
Use of plants as a source of traditional healing systems around the world that utilize herbal remedies is an important source for the discovery of new antimicrobials against resistant strains of bacteria. It is being used as a source of medicinal agents for antibacterial, antihelminthic, astringent, emetic, sedative and stimulant. A 10 g dried leaves powder of Woodfordia fruticosa was extracted separately in each different solvent i.e., aqueous, ethanol and methanol. The extract was stored at 4ºC in airtightbottles until further uses. Total 8 strains including gram positive and gram negative bacteria were selected to assess the susceptibility test against the different drug extract. These are Escherichia coli (ATCC-25922), Pseudomonas aeroginosa (ATCC-27853), Salmonella paratyphi (ATCC-9150), Salmonella typhimorium (ATCC-25241), Shigella sonnei (ATCC-25931), klebseilla pneumonia (ATCC-27736), Staphylococcus aureus (ATCC-25923) and Proteus vulgaris (ATCC-6380). The antibacterial activity was performed in vitro using Agar well diffusion assay and diameter of zone of inhibition was measured. The Methanolic shows good zone of inhibition in almost bacteria. The highest zone of inhibition was observed in...
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Posted by admin on Aug 1, 2013 in |
In the last few decades, to synthesize the different new heterocyclic compounds along their derivatives which were evaluated for their biological activities as antimicrobial, antiviral, antitumor, anticonvulsant, antifungal, the triazole moiety seems to be very small but in the biological profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. In this review we provides a brief response of the medicinal chemistry of 1, 2, 4-triazole and its derivatives. A literature survey of procedures for the preparation of 1, 2, 4-triazole and 1, 2, 3-triazoles is presented by generalized synthetic...
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Posted by admin on Aug 1, 2013 in |
A Streptomyces strain was isolated from soil and was identified as Streptomyces spectabilis on the basis of 16 S rRNA gene sequencing. On screening for its ability to produce antimicrobial compounds, it was found to be active only against Gram positive bacteria. Attempts were made to optimize the culture conditions for the production of antimicrobial compounds. Basal medium supplemented with glucose as a carbon source was found to be the best for growth but not for antibiotic production. Antibiotic production proved to be highest in the medium amended with cellobiose. Jack bean meal (JBM) and peptone were the best nitrogen sources for growth and antibiotic production respectively. Antibiotic production appeared to start after 48 hours and reached a maximum on the fourth day. Maximum growth and antibiotic production occurred when the initial pH was adjusted to...
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