Posted by admin on May 31, 2018 in |
Pogostemon quadrifolius (Benth.) is a medicinal aromatic shrub in family Lamiaceae which is used as folk medicine in India. This present study deals with the preliminary screening of Pogostemon quadrifolius antimicrobial activity and TLC profiling of the crude plant extract. Cold extraction technique was carried out to prepare the crude plant extract, which was further screened for the presence of phytochemicals. The extracts were assessed for antibacterial and antifungal studies by disc diffusion method. Thin layer chromatography was utilized for solvent standardization. Phytochemical analysis revealed the presence of diverse classes of bioactive components. The quantitative analysis of flavanoids, alkaloids and total phenolic content in different extracts varied from each other. Evaluation of antibacterial studies showed that methanolic extract and ethyl acetate extract showed activity against standard and MDR strains respectively. The ethanolic extract also showed fungicidal activity. And finally the solvent standardization was performed for the separation of phyto-constituents by TLC, which showed a very good abundance of active principles (based on their Rf values). All these preliminary reports...
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Posted by admin on May 31, 2018 in |
Selenium nanoparticles are attracting more and more attention due to their excellent photoelectrical characteristics and high biological activity. Selenium is also found to be effective against cancer. ZnO nanoparticles are reported to inhibit the growth of a wide range of pathogenic bacteria under normal visible lighting conditions. In this research work, we report the preparation of a set of Selenium doped ZnO nanoparticles (Zn1-xSexO1-δ; where x = 0.05, 0.10, 0.15 and 0.20) by simple chemical synthesis method. The materials were characterized systematically by X-ray Diffraction method, FT-IR spectroscopy, particle size analysis, SEM, EDAX analysis and TEM. The physical characterization studies have revealed the presence of fine particles in the prepared crystalline materials. The prepared materials were also subjected to antimicrobial assay by agar well diffusion method against both Gram positive (Staphylococcus aureus and Bacillus subtilis) and Gram negative bacteria (Escherichia coli and Klebsiella pneumoniae). Among studied, the material with the composition the materials Zn0.80Se0.20O1-δ have exhibited excellent antibacterial activity against the bacteria such as, Bacillus subtilis and Staphylococcus aureus....
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Posted by admin on Apr 30, 2018 in |
In this work, an attempt was made to synthesize new chalcones by Claisen – Schmidt condensation of substituted benzaldehydes with 4-aminoacetanilide in the presence of base catalyst. The synthesized chalcone derivatives was characterized by FT-IR, 1H-NMR, and 13C-NMR and also tested for their antimicrobial activity and compared with the standard...
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Posted by admin on Mar 31, 2018 in |
Coconut shell oil was extracted from raw coconut shells, collected from Thiruvallur District. These were extracted using various solvents based on the polarity which includes ethanol, chloroform, acetone, petroleum ether and aqueous. The antibacterial activity against the growth of Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Klebsiella pneumonia, Pseudomonas aeruginosa and Salmonella typhi was done. The antifungal activity against the growth of organisms such as Epidermophyton floccosum, Aspergillus niger, Penicillium, Microsporum canis, Candida albicans and Aspergillus flavus were tested. The extracts were compared with standards like novobiocin, amoxillin and ketoconazole for antibacterial and antifungal activity respectively. The results indicate that zone of inhibition increased when increasing the concentration of the extracts. Among the five extracts of coconut shell oil the ethanolic extract exhibited maximum antibacterial activity against six bacterial strains. Ethanol and petroleum ether extract showed maximum inhibitory activity against Epidermophyton and Candida albicans. This study showed that coconut shell oil possesses antimicrobial...
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Posted by admin on Feb 28, 2018 in |
Endophytic actinomycetes are the potential source for obtaining novel bioactive compounds. Present study evaluates the chemical constituents in Ocimum basillicum and its endophytic actinomycetes. Eleven endophytic actinomycetes were isolated from O. basillicum plant. Among eleven, one isolate was characterized by 16S rRNA and identified as Streptomyces flavoviridis A3WK. A comparative analysis of the FT-IR, GC-MS, antibacterial, antioxidant and anti-inflammatory properties of plant and endophytic actinomycetes extracts was conducted. 12 compounds each of Streptomyces flavoviridis A3WK and O. basillicum were identified by GC-MS. The FT-IR and GC-MS analysis reveals that S. flavoviridis A3WK has more antimicrobial, antioxidant activity and anti-inflammatory properties compared with the results of O. basillicum. Over all the activity of the endophytic actinomycetes was more compared to that of the O. basillicum extracts. The study reveals to show that the existence of endophytic actinomycetes may enhances medicinal value of the medicinal plants, and hence such studies help in the study of endophytic actinomycetes as well as their relevance in host...
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